2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Support Documents
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- EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments, Volume 1 (PDF) (2012) (344 pp, 3.8M)
This document comprises the first of two EPA reports (U.S. EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments Volumes 1 and 2 [Reanalysis Volumes 1 and 2]) that, together, will respond to the recommendations and comments on 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) dose-response assessment included in the 2006 NAS report, Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment. This document, Reanalysis Volume 1, includes (1) a systematic evaluation of the peer-reviewed epidemiologic studies and rodent bioassays relevant to TCDD dose-response analysis; (2) dose-response analyses using a TCDD physiologically based pharmacokinetic model that simulates TCDD blood concentrations following oral intake; and (3) an oral reference dose (RfD) for TCDD.
- Appendices for Toxicological Review of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (PDF) (1521 pp, 13.5M) (Appendices only)
- Supporting Reference: Recommended Toxicity Equivalence Factors (TEFs) for Human Health Risk Assessments of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Dioxin-Like Compounds (December 2010)
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) IRIS Assessment Summary (2012)
- EPA's Dioxin Website
Similar support documents can be found in the List of Available IRIS Toxicological Reviews and Other Support Documents.