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The National Center for Computational Toxicology (NCCT) is a part of EPA's Office of Research and Development (ORD). Located in Research Triangle Park, North Carolina, NCCT coordinates and implements EPA's research in the field of computational toxicology. NCCT scientists serve as scientific reviewers and advisors by providing technical assistance to other Laboratories and Centers within ORD, to EPA Program Offices and Regions, and to the states. Additionally, NCCT serves as a source of training in computational toxicology by offering seminars, mini-courses, symposia, and staff details.

NCCT is committed to collaborating with other governmental and private organizations to leverage external resources whose complementary expertise can help EPA accelerate progress in high priority research areas. NCCT works closely with the STAR-funded Center for Environmental Bioinformatic Research to provide tools and training to broader scientific audiences and sponsors external research in the field of computational toxicology conducted in support of EPA's mission.

Read more about the science of Computational ToxicologyRead more about the science of Computational Toxicology

bullet image The National Center for Computational Toxicology is now accepting applications for the 2010 Rotational Fellowship Program. (02.03.09)

This Fellowship program is intended to help translate the technologies and approaches being developed within the NCCT to other parts of the Agency. This is a great opportunity for interaction, collaboration and facilitation of Computational Toxicology. Read more about the Rotational Fellowship Program

bullet image NCCT Announces Public Release of ToxCast Phase I Data in Conjunction with Publication of Major ToxCast Overview Paper. (12.14.09)

A paper titled "In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization – The ToxCast Project", describing the first phase of ToxCast has just been published in Environmental Health Perspectives. ToxCast aims to evaluate the use of in vitro assays for understanding the types of molecular and pathway perturbations caused by environmental chemicals and to build initial prioritization models of in vivo toxicity. The collection of data generated by ToxCast Phase I is now posted on the EPA ToxCast web site: http://www.epa.gov/ncct/toxcast. Read the full article.

bullet image $3.2M Awarded to the University of Houston for a Comp-Tox Developmental Toxicity Center (8.19.09)

EPA has awarded $3.2M to the University of Houston to develop a virtual developmental toxicity research center with Texas A&M and the University of Indiana. The Texas Indiana Virtual STAR (TIVS) Center will contribute to the evolution of more reliable chemical risk assessments by developing high throughput in vitro and in silico screening models of developmental toxicity. The models will use zebrafish embryonic stem cells to analyze the effects of toxic chemicals on the developing embryo. Read the full article.

bullet image Scientists Convene to Discuss New Method to Study How Toxic Chemicals Impact Human Health (5.29.09)

More than 200 scientists, regulators, and policy makers from around the world convened recently at EPA's first ToxCast™ Data Analysis Summit to discuss results of the first phase of ToxCast™. ToxCast™ is an innovative approach for profiling how chemicals in our environment impact important biological pathways that are critical for the function of the body's systems such as the heart, lungs, brain or reproductive organs. Read the complete news release.

bullet image New and Improved DSSTox Structure Browser for Chemical Analog Searching (8.12.09)

The DSSTox Structure Browser v2.0 includes a number of new features to facilitate flexible text (Chemical Name, CAS) and chemical structure searching through 11 published DSSTox Data Files, currently spanning over 6000 chemical structures. New to the Browser are External link-outs based on chemical structure to public resources that include: PubChem, ChemSpider, Lazar In Silico Toxicology, and soon-to-be-activated, ACToR. More Information on DSSTox Structure Browser Update v2.0.

bullet image Computational Toxicology Implementation Plan

Implementation Plan

ORD's Computational Toxicology Research Program Implementation Plan lays out the rationale and short to medium term objectives of the research program in computational toxicology.

The plan discusses the three main components of the program, and details the research issue and relevance, experimental approach, progress to date and milestones over the next three years for each.
Read the Full Implementation Plan (PDF, 100 pp., 930 kb, About PDF)

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