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Research Data Disclaimer

The National Center for Computational Toxicology (NCCT) is committed to public disclosure of the information and databases compiled in pursuit of developing new approaches for characterizing environmental hazards and risks. Upon appropriate review for quality, management oversight, and Agency policy implications, NCCT is releasing this information and databases through our websites in order to facilitate computational toxicology research. Potential users should be aware of the methods used to collect the data and potential limitations in interpreting these findings. For example, animal toxicology information has undergone rigorous quality review, but this information alone should not be construed as indicators of human risk; the Agency considers many factors in the process of interpreting such information relative to human risk. Much of NCCT's data are high throughput screening (HTS) results from titration series providing concentration-response outputs for test compounds. Investigators using these HTS data should remain cognizant of the following:

  1. The compound sample tested is limited in quantity, so in most cases the NCCT cannot supply screening samples. Some samples are commercially available and inexpensive, and can be purchased directly from vendors.
  2. The effect of the sample on the assay may reflect artifacts resulting from sample physical properties, such as interference in the assay due to aggregation, or absorbance of emitted fluorescence for signal detection. Indicators of sample potential for interference will be added to the data set as determined.
  3. QC information is not necessarily current. Subsequent chemical analysis and verification of activity is being performed on a subset of actives, and added to the data set periodically.
  4. The IC50/EC50 values determined from the normalized titration-response data are estimates. Curve fitting artifacts can occur due to the high throughput nature of the analysis. Updates on verification and confidence of curve fits will be provided periodically. In most cases, the primary data are available for interpretation by others.

The EPA, through its Office of Research and Development, manages the research described herein, and the data have been subjected to internal technical review and approved for posting to this web site or database. In most cases, the data have also undergone external peer-review and publication in a scientific journal. Although these data were reviewed and approved for research use, they may not necessarily reflect official EPA policy. Mention of trade names or commercial products does not constitute endorsement or recommendation by EPA for use.

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