Benchmark Dose Software (BMDS)
Upcoming USEPA Hands-On BMDS Training
Periodically, EPA provides on-site or webinar-based training workshops on the application of BMD methodologies, including basic modeling concepts and use of more advanced modeling options. Training is usually given at the Society of Risk Analysis’ annual meeting. Also, if your organization would like to request a personalized training workshop, please contact J. Allen Davis.
Listed below are the currently scheduled training workshops; if no training is listed, please check back periodically as training workshops are added to the schedule throughout the year.
- BMDS Training, SRA 2014 Annual Meeting (Dec 7-10). Details TBA.
Benchmark Dose Modeling
Organizers: J. Allen Davis,
Instructors: J. Allen Davis, Jeff Gift , Jay Zhao
Registration fee: TBA
Location: Denver, CO
Preliminary Date: December 7, 2014
Society for Risk Analysis website: TBA
The objective of this full-day course is to provide participants with interactive training on the use of the U.S. Environmental Protection Agency’s (EPA) Benchmark Dose Software (BMDS) and its application to risk assessment. Benchmark dose (BMD) modeling involves fitting mathematical models to dose-response data in order to identify points of departure for use in human health risk assessments. BMD modeling addresses many of the limitations of the traditional No Observed Adverse Effect Level (NOAEL) approach. In this interactive training workshop, EPA instructors will present: the basic theory of BMD modeling (including selection of a benchmark response level, model fitting and comparison), a demonstration of EPA’s BMDS 2.5, and individual and group modeling exercises. Instructors will focus on the use of the Excel-based BMDS Wizard templates that are provided with BMDS 2.5, including the newly developed MS_Combo Wizard template. The BMDS Wizard streamlines BMD analyses by allowing users to build BMDS inputs, run models, and import results in Excel. In addition to importing all results, the BMDS Wizard is capable of recommending best-fitting models using customizable decision criteria.
It is recommended that users familiarize themselves with basic BMD concepts through the online tutorial and training materials provided on the EPA BMDS website (http://epa.gov/ncea/bmds/training/index.html).
Participants need to bring their own laptops, with BMDS 2.5 installed, to the workshop. The latest version of the software program can be found at: http://epa.gov/ncea/bmds/. In order to use the BMDS Wizard templates, Microsoft Excel must also be installed on the users’ laptops.
Disclaimer: The views expressed in this abstract are those of the authors and do not necessarily reflect the views or policies of the U.S. EPA.
- Benchmark Dose Modeling – CLU-In webinars
The objective of this webinar series is to provide webinar-based, interactive training on the use of the U.S. Environmental Protection Agency’s (EPA) Benchmark Dose Software (BMDS) and its application to risk assessment. Use of BMD methods addresses many of the limitations of the traditional No Observed Adverse Effect Level (NOAEL) approach. BMD modeling involves fitting mathematical models to dose-response, and in some cases dose-time-response, data in order to identify points of departure for use in human health risk assessments. This series of webinars will consist of individual training modules focusing on a specific type of data or topic:
Session 1 (June 3, 2014: 1:00 PM – 4:30 PM, EDT)
- Introduction – this training module will introduce users to the basic science and theory of BMD modeling and the advantages it holds over the NOAEL approach
- Dichotomous Models – these models describe the dose-response relationship for effects that are measured as incidence
- Continuous Models – models for describing the dose-response characteristics of effects measured on a continuous scale (e.g., body weight)
- Nested Dichotomous Models – these models are modified dichotomous models that can describe the inter-litter effects often observed in developmental toxicity studies
- Cancer Modeling – this module will cover the modeling of cancer data, including modeling individual tumors, modeling multiple tumors within a single bioassay, and modeling tumors when survival rates are observed to differ across exposures
- Modeling Time – these models can characterize the dose-time-response relationship when animals are exposed for varying durations of time or responses are measured at multiple time points
Each training webinar will be presented as a standalone unit, so users can attend only the webinars of interest of them and still receive a complete and valuable training experience. General topics that will be covered in each webinar include 1) basic BMD modeling workflows, 2) selection of appropriate benchmark response levels, 3) judging model fit, and 4) demonstrations of EPA’s BMDS package and the Excel-based BMDS Wizard templates (where appropriate).
Although it is not necessary for participants to attend every webinar, it is highly recommended that all attend the Introduction module, especially if they have no previous BMD experience. If users wish, they can familiarize themselves with basic concepts through the online tutorial and training materials provided on the EPA BMDS website (http://epa.gov/ncea/bmds/training/index.html).
Participants will need to have version of BMDS 2.5 installed (with necessary administrative rights). The latest version of the software program can be found at: http://epa.gov/ncea/bmds/. Additionally, in order to use the BMDS Wizard templates, Microsoft Excel must be installed on the user’s computers. For participants of the Modeling Time webinar, the R statistical package (preferably version 3.1.0) must also be installed on their computers.