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Recent Additions

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Find notifications (by year) of new IRIS Summary and Toxicological Review postings to IRIS, Federal Register notices, peer review meetings and other announcements about the IRIS Program and Web site. If you like to receive notifications of Recent Addition items, please contact us.

Federal Register Notices about IRIS are also available on the US Government Printing Office (GPO) website.

23 December 2014

EPA announces the availability of the final report, SUMMARY REPORT: State-of-the-Science Workshop on Chemically-Induced Mouse Lung Tumors: Applications to Human Health Assessments. EPA hosted a two-day, state-of-the-science workshop in January 2014, which covered a broad range of evidence from human, animal, and in vitro studies with a focus on specific chemicals (ethylbenzene, naphthalene, and styrene) that cause lung tumors in mice and are implicated in a proposed species-specific mode of action (MOA) based on metabolic and physiological susceptibility. The report is a brief summary of the proceedings of the workshop.

15 December 2014

EPA is announcing the schedule and dates for the 2015 IRIS Bimonthly Public Science Meetings in the Federal Register.  The meeting dates are posted on the IRIS public meeting page and will include meeting materials before each meeting. [Federal Register Notice Dec 15, 2014]

11 December 2014

EPA announces the availability of the presentations from the NRC Recommendations for IRIS Workshop and the presentations from the October 2014 bimonthly science meeting.

8 December 2014

EPA is announcing Dibutyl Phthalate (DBP) has been added to the agenda for the February 2015 Bimonthly Public Meeting.  The preliminary materials for DBP will be released in mid-January 2015.  The deadlines for DBP discussant registration and comments are posted on the February 25-26, 2015 IRIS Bimonthly Public Meeting.

8 December 2014

EPA is announcing the release of the final IRIS Summary for Libby Amphibole asbestos and an accompanying toxicological review, fact sheet, and frequently asked questions that have been added to the IRIS website. The Interagency Science Discussion Draft of the Libby Amphibole Asbestos IRIS Assessment was also released. [Press Release December 8, 2014]

21 November 2014

EPA has canceled the December Bimonthly Public Science Meeting on BBP and DIBP and will discuss these chemicals at the February 25-26, 2015 IRIS Bimonthly Public Meeting. On October 15, 2014, EPA’s IRIS Program announced an agreement with the National Academies’ National Research Council (NRC) to arrange for independent experts input on the science underlying the development of IRIS assessments through participation in IRIS Bimonthly Public Science Meetings. These independent experts, speaking on their own behalf, will contribute to the scientific discussions of issues amongst EPA, stakeholders, and the public. This meeting will be the first meeting where NRC identified experts will join the public discussion on preliminary assessment materials.

17 November 2014

EPA's Science Advisory Board (SAB) office announced the dates for two meetings of the Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of ammonia; the first scheduled for (12/17/2014) and the second for (12/19/2014). A revised draft of the assessment was posted on the IRIS web site in August 2013, when it is transmitted to the SAB for review. Please visit the SAB website for additional information.  Any related questions should be directed to the SAB.  [SAB FR Notice November 17, 2014]

6 November 2014

EPA is announcing the schedule and dates for the 2015 IRIS Bimonthly Public Science Meetings.  The meeting dates are posted on the IRIS public meeting page and will include meeting materials before each meeting.

24 October 2014

EPA announces registration is now open for the December Bimonthly Public Science Meeting and key science issues are posted on the meeting website.

15 October 2014

In October, EPA announced that IRIS Bimonthly Public Science Meetings will be supplemented by scientific experts identified by the National Academies’ National Research Council (NRC).   These independent experts will provide valuable scientific input and broaden the range of perspectives represented at our public meetings. [IRIS Announcement October 15, 2014]

8 October 2014

EPA posted the agenda and key science issues for the upcoming the IRIS Public Science Meeting (scheduled for October 29-30, 2014 in Arlington, VA) to discuss preliminary materials for the draft development of the IRIS assessments of Diisononyl Phthalate (DINP) and Hexavalent Chromium (Cr(VI)). Registration is still open.

29 September 2014

EPA announces the availability of preliminary materials (literature search and search strategy, evidence tables, and exposure-response figures) for diisobutyl phthalate (DIBP) and butyl benzyl phthalate (BBP) for public review and comment. These materials will be discussed at the upcoming December IRIS public science meeting scheduled for December 15-16, 2014 in Arlington, Virginia. Key science questions will be posted, and registration will open, by mid-October 2014.

25 September 2014

EPA transmitted the latest update of the external review draft of the benzo[a]pyrene assessment to the SAB for peer review by the SAB Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of benzo[a]pyrene (CAAC-Benzo[a]pyrene panel).  Additionally, the draft assessment and charge to the peer reviewers were made available on the IRIS website.  Please visit the SAB website for additional information.  Any related questions should be directed to the SAB.

25 September 2014

EPA posted the agenda for the upcoming the IRIS workshop to discuss the NRC recommendations.

4 September 2014

EPA announces the availability of preliminary materials (literature search and search strategy, evidence tables, and exposure-response figures) for hexavalent chromium (Cr(VI)) for public review and comment. These materials, and key science questions related to the assessment, will be discussed at the upcoming October IRIS public science meeting scheduled for October 29-30, 2014 in Arlington, Virginia. Meeting registration is now open.

29 August 2014

EPA announced the availability of preliminary materials (literature search and search strategy, evidence tables, and exposure-response figures) for diisononyl phthalate (DINP) for public review and comment. These materials, and key science questions related to the assessment, will be discussed at the upcoming October IRIS public science meeting scheduled for October 29-30, 2014 in Arlington, Virginia. Meeting registration will open the first week in September 2014.

29 August 2014

EPA posted the EPA presentations for the upcoming the September bimonthly science meeting.

27 August 2014

EPA posted the presentations from the June 2014 bimonthly science meeting.

15 August 2014

EPA transmitted the revised external review draft of the ethylene oxide assessment to the SAB for peer review by the SAB Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of ethylene oxide (CAAC-Ethylene oxide panel).  Additionally, the draft assessment and charge to the peer reviewers were made available on the IRIS website.  Please visit the SAB website for additional information.  Any related questions should be directed to the SAB.  [SAB FR Notice August 11, 2014]

11 August 2014

EPA's Science Advisory Board (SAB) office announced the dates for two meetings of the Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of ethylene oxide; a public teleconference (09/30/2014) and a face-to-face meeting (11/18 through 11/20/2014). A draft of the assessment will be posted on the IRIS web site on or about August 15th, when it is transmitted to the SAB for review. Once the draft is posted, please visit the SAB website for additional information.  Any related questions should be directed to the SAB.  [SAB FR Notice August 11, 2014]

25 July 2014

EPA announced the availability of problem formulation materials and opens registration for the September IRIS Public Science Meeting, September 3-4, 2014.

24 July 2014

EPA posted the presentations from the April 2014 bimonthly public meeting.

29 May 2014

EPA is planning a public workshop to discuss some specific recommendations from the National Academies’ National Research Council’s May 2014 report on IRIS related to further improving the scientific quality of IRIS assessments. In their report, the NRC commended EPA for its substantive new approaches, continuing commitment to improving the process, and successes to date. They noted that the program has moved forward steadily in planning for and implementing changes in each element of the assessment process. They also provided several recommendations which they said should be seen as building on the progress that EPA has already made. This workshop will allow us to get input from the public and scientific community about some specific topics related to the NRC’s May 2014 recommendations. The workshop will take place October 15-16, 2014, in the Washington, DC area, and it will be available by webinar. Specific details, including the location, agenda, and how to register, will be available at a later date.

6 May 2014

The National Academies National Research Council (NRC) released their review of the IRIS assessment development process. The NRC report applauds EPA's efforts to improve IRIS and finds that the Program has moved forward steadily in planning for and implementing changes in each element of the assessment process. Their report notes that the IRIS Program has made substantial progress in a short time, and the committee offers recommendations which build on the progress that EPA has already made.
[EPA Press Release May 6, 2014] [NAS Press Release May 6, 2014]

1 May 2014

EPA's Science Advisory Board (SAB) CAAC posted the agenda for the upcoming public teleconference meeting to dicuss the review of the draft IRIS trimethylbenzene assessment, the meeting will take place on May 22, 2014. See the SAB website site for additional details.

30 April 2014

EPA announced the availability of key science issues specific to inorganic arsenic and hexavalent chromium for the upcoming June IRIS public science meeting scheduled for June 25-27, 2014 in Arlington, Virginia. Registration is now open.

25 April 2014

EPA announced the availability of preliminary materials (literature search and search strategy, evidence tables, and exposure-response figures) for inorganic arsenic for public review and comment. These materials, and key science issues related to the assessment, will be discussed at the upcoming June IRIS public science meeting scheduled for June 25-27, 2014 in Arlington, Virginia.

17 April 2014

EPA announced the availability of preliminary materials (literature search and search strategy, evidence tables, and exposure-response figures) for hexavalent chromium (Cr(VI)) for public review and comment. These materials, and key science issues related to the assessment, will be discussed at the upcoming June IRIS public science meeting scheduled for June 25-27, 2014 in Arlington, Virginia.

16 April 2014

A final agenda is now available for the April IRIS Bimonthly Public Meeting. The meeting will be held on April 23, 2014 (the second day, April 24, is no longer needed).

9 April 2014

EPA's Science Advisory Board (SAB) Staff Office previously announced in the Federal Register (March 25, 2014) an incorrect date for the teleconference of the SAB Chemical Assessment Advisory Committee Augmented for the Review of the Draft Ammonia Assessment (CAAC-Ammonia Panel), the correct date is June 2, 2014 from 1 - 5pm. [SAB FR Notice for April 9, 2014]

4 April 2014

A draft agenda is now available for the April IRIS Bimonthly Public Meeting. The meeting will be held on April 23, 2014 (the second day, April 24, is no longer needed).

An updated preliminary Agenda is now available for the Formaldehyde Workshop,
which will be held on April 30 and May 1, 2014, in the Washington D.C. metro area. A final agenda, additional workshop details, and a specific location will be announced in the near future.

26 March 2014

EPA confirmed the dates for the Formaldehyde Workshop to be held April 30 - May 1, 2014. The workshop is part of EPA's efforts in revising its Integrated Risk Information System (IRIS) toxicological assessment of formaldehyde. This assessment addresses both noncancer and cancer human health effects that may result from chronic inhalation exposure to formaldehyde. To facilitate discussion of several scientific issues pertinent to the assessment, EPA will convene a public state-of-the-science workshop and webinar to discuss these issues.

25 March 2014

EPA's Science Advisory Board (SAB) Staff Office announced two meetings of the SAB Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of ammonia; a public teleconference (06/04/2014) and a face-to-face meeting (07/14 through 7/16/2014). Please visit the SAB website for additional information. Any related questions should be directed to the SAB. [SAB FR Notice for Ammonia March 25, 2014]

25 March 2014

EPA's Science Advisory Board (SAB) Staff Office announced two meetings of the SAB Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of trimethylbenzenes; a public teleconference (5/22/2014) and face-to-face meeting (06/17 through 06/19/2014). Please visit the SAB website for additional information. Any related questions should be directed to the SAB. [SAB FR Notice for TMBs March 25, 2014]

13 March 2014

EPA announced the availability of a new general comments docket for the IRIS Program. This docket will be used to accept public comments that have broad applicability to the IRIS Program, which may include comments on general scientific issues that apply to all assessments and/or other non-chemical-specific comments about the IRIS Program. Our intent is to promote transparency and an open dialogue within the IRIS stakeholder community, therefore commenters are asked to please identify themselves and provide contact information with each submission. This docket does not replace the IRIS Hotline, but rather provides another avenue to submit feedback to the IRIS Program.

6 March 2014

EPA announced the availability of preliminary materials (literature search and search strategy, evidence tables, and exposure-response figures) for diethyl phthalate (DEP) and hexabromocyclododecane (HBCD) for public review and comment. This announcement came with a special message from the IRIS Program. These chemicals will be discussed at the IRIS bimonthly public meeting scheduled for April 23-24th in Arlington, Virginia. Registration is open.

26 February 2014

EPA confirmed the dates for the April 2014 IRIS Bimonthly Meeting to be held April 23-24, 2014 in Arlington, VA. At this upcoming meeting, the IRIS Program will explore a new format intended to promote public discussion of key issues for several assessments under development. The new format is responsive to public comments heard at the December 2013 bimonthly public meeting and reflects the Program’s continuing evolution in response to public comments and peer review advice.

20 February 2014

EPA announced that they will host a workshop to discuss several scientific issues related to its draft Integrated Risk Information System assessment of formaldehyde (inhalation exposure). The workshop will focus on three areas: (1) Epidemiological research examining the potential association between formaldehyde exposure and lymphohematopoietic cancers (leukemia and lymphomas); (2) Mechanistic evidence relevant to formaldehyde inhalation exposure and these types of cancers; and (3) Evidence pertaining to the influence of formaldehyde that is produced endogenously (by the body during normal biological processes) on the toxicity of inhaled formaldehyde, and implications for the health assessment. We will confirm the workshop dates in the very near future. Additionally, we anticipate posting a draft agenda in early March and a final agenda by late March.

12 February 2014

EPA rescheduled the February 18-20, 2014 Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) Review Meeting to provide the public with additional time to prepare. The purpose of this public meeting is for the SAB CAAC to peer review the draft IRIS assessments of ammonia and trimethylbenzenes (1,2,3-, 1,2,4- and 1,3,5-trimethylbenzene) to provide advice to the Agency through the chartered SAB. Rescheduling the meeting is responsive to stakeholder requests, will provide the public with additional time to prepare for the meeting, and is consistent with the IRIS Program’s practice of providing approximately two months advance notice of its public meetings and the SAB’s commitment to provide at least 45 days advanced notice of meetings. The EPA SAB staff office will reschedule the peer reviews of these draft assessments. Additional information will be provided in the near future.

30 January 2014

EPA's Science Advisory Board (SAB) Staff Office announced three public meetings. The SAB Chemical Assessment Advisory Committee (CAAC) and additional experts will meet in a plenary session to learn about new enhancements to the EPA's process for IRIS health assessments for chemicals. Additional announcements will be posted in the Federal Register. [Federal Register Notice: Jan 30, 2013]

29 January 2014

EPA's Science Advisory Board (SAB) Staff Office requested nominations for experts to augment the SAB Chemical Assessment Advisory Committee (CAAC) for the review of the EPA's Draft IRIS Assessment for benzo[a]pyrene (BaP). [Federal Register Notice Jan 28, 2014]

16 January 2014

EPA cancelled the February 26-27, 2014, IRIS bimonthly public meeting to allow time to prepare additional materials that will promote more robust discussions at future public meetings based on public comments heard at the December bimonthly public meeting.  The next meeting will be held in April 2014.

7 January 2014

EPA posted the presentations from the IRIS December Bimonthly Meeting

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