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Acceptable Substitutes in Industrial Process Air Conditioning

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Unacceptable substitutes

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Acceptable Substitutes for CFCs (class I ODS) in Industrial Process Air Conditioning

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HCFC-124   114 R, N
Ikon A   12 R, N
Ikon B   12 R, N
THR-02   12 R, N
HCFC-22   114 N (below 115 degrees F ambient)
HFC-134a   114 N (below 125 degrees F ambient)
R-401A, R-401B MP-39, MP-66 114 R
FOR12A FOR12A 12 R, N
FOR12B FOR12B 12 R, N
Hot Shot (HCFC Blend Omicron) Hot Shot, Kar Kool, 414B 112, 114 R, N
RS-24 (2002 formulation)   12 R, N
ISCEON 59, NU-22, R-417A ISCEON 59, NU-22 12 R, N
R-407C Suva 407C, Klea 407C 502 R, N
R-420A Choice R-420A 12, 500 R, N
R-421B Choice R421B 12, 502 R, N
R-426A RS-24 12 R, N
R-422C ICOR XLT1 502 R, N
HFC-245fa Genetron® 245fa 114 R, N
KDD6 KDD6 12 R, N
R-450A Solstice N–13   R, N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Industrial Process Air Conditioning

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
R-410A AZ-20, Suva 9100, Puron 22 and blends containing HCFCs N
R-410B   22, blends containing 22 and/or 142b N
THR-03   22 N
ISCEON 59, NU-22, R-417A ISCEON 59, NU-22 22, blends containing 22 and/or 142b R, N
R-407C Suva 9000, Klea 66 22 and blends containing HCFCs R, N
R-507, R507A AZ-50 22 and blends containing HCFCs R, N
Ammonia Vapor Compression   22, blends containing 22 and/or 142b N
Ammonia Absorption   22, blends containing 22 and/or 142b N
Evaporative Cooling   22, blends containing 22 and/or 142b N
Desiccant Cooling   22, blends containing 22 and/or 142b N
R-404A HP62 22 and blends containing HCFCs R, N
R-125/134a/600a(28.1/70.0/1.9) NU-22 old composition 22, blends containing 22 and/or 142b R, N
RS-44 (2003 formulation)   22, blends containing 22 and/or 142b R, N
R-421A Choice R421A 22, blends containing 22 and/or 142b R, N
R-422D ISCEON MO29 22, blends containing 22 and/or 142b R, N
R-424A RS-44 22, blends containing 22 and/or 142b R, N
R-426A RS-24 22, blends containing 22 and/or 142b R, N
KDD5, R-438A ISCEON MO99 22, blends containing 22 and/or 142b R, N
R-434A RS-45 22, blends containing 22 and/or 142b R, N
R-125/290/134a/600a (55.0/1.0/42.5.1.5) ICOR AT-22 22, blends containing 22 and/or 142b R, N
R-422B XAC1, NU-22B 22, blends containing 22 and/or 142b R, N
R-422C XLT1 22, blends containing 22 and/or 142b R, N
R-427A Forane 427A 22, blends containing 22 and/or 142b R
HFC-134a   22, blends containing 22 and/or 142b R, N
RS-24 (2002 formulation)   22, blends containing 22 and/or 142b R, N
R-423A ISCEON 39TC 22, blends containing 22 and/or 142b R, N
R-407F  Genetron Performax LT 22, blends containing 22 and/or 142b  R, N
R-450A Solstice N–13   R, N
Key: R = Retrofit Uses, N = New Uses

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