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Acceptable Substitutes in Industrial Process Air Conditioning

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Unacceptable substitutes

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Acceptable Substitutes for CFCs (class I ODS) in Industrial Process Air Conditioning

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HCFC-124   114 R, N
Ikon A   12 R, N
Ikon B   12 R, N
THR-02   12 R, N
HCFC-22   114 N (below 115 degrees F ambient)
HFC-134a   114 N (below 125 degrees F ambient)
R-401A, R-401B MP-39, MP-66 114 R
FOR12A FOR12A 12 R, N
FOR12B FOR12B 12 R, N
Hot Shot (HCFC Blend Omicron) Hot Shot, Kar Kool, 414B 112, 114 R, N
RS-24 (2002 formulation)   12 R, N
Isceon 59, NU-22, R-417A Isceon 59, NU-22 12 R, N
R-407C Suva 407C, Klea 407C 502 R, N
R-420A Choice R-420A 12, 500 R, N
R-421B Choice R421B 12, 502 R, N
R-426A RS-24 12 R, N
R-422C ICOR XLT1 502 R, N
HFC-245fa Genetron® 245fa 114 R, N
KDD6 KDD6 12 R, N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Industrial Process Air Conditioning

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
R-410A, R-410B AZ-20, Suva 9100, Puron 22 N
THR-03   22 N
ISCEON 59   22 N
R-407C Suva 9000, Klea 66 22 R, N
R-507, R507A AZ-50 22 R, N
Isceon 59, NU-22, R417A Isceon 59, NU-22 22 R, N
Ammonia Vapor Compression   22 N
Ammonia Absorption   22 N
Evaporative/Desiccant Cooling   all HCFCs N
R-404A HP62 22 R, N
R-125/134a/600a(28.1/70.0/1.9)   22 R, N
RS-44 (2003 formulation)   22 R, N
R-421A Choice R421A 22 R, N
R-421B Choice R421B 22 R, N
R-422D ISCEON MO29 22 R, N
R-424A RS-44 22 R, N
R-426A RS-24 22 R, N
KDD5, R-438A ISCEON MO99 22 R, N
R-434A RS-45 22 R, N
R-125/290/134a/600a (55.0/1.0/42.5.1.5) ICOR AT-22 22 R, N
R-422B XAC1, NU-22B 22 R, N
R-422C XLT1 22, 402A, 402B, 408A R, N
R-427A Forane 427A 22 R
Key: R = Retrofit Uses, N = New Uses

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