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Acceptable Substitutes for CFC-12, R-500, and HCFC-22 in Centrifugal Chillers

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Unacceptable substitutes

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Acceptable Substitutes for CFC-12 & R-500 (class I ODS) in Centrifugal Chiller

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HCFC-22   12, 500 N
HCFC-123   12, 500 N
HFC-134a   12, 500 R, N
Ikon A   12 R, N
Ikon B   12 R, N
HFC-227ea   12, 500 N
R-406A GHG 12, 500 R, N (R-500 only)
Free Zone (HCFC Blend Delta) Free Zone / RB-276 12, 500 R, N
Freeze 12 Freeze 12 12, 500 R, N
FRIGC FR-12 (HCFC Blend Beta) FRIGC FR-12 12, 500 R, N
GHG-X4 GHG-X4, Autofrost, Chill-it 12, 500 R, N
GHG-X5 GHG-X5 12, 500 R, N
G2018C G2018C 12, 500 R, N
Hot Shot Hot Shot, Kar Kool 12, 500 R, N
HCFC-22/HCFC-142b   12 R, N
R-420A Choice R-420A 12, 500 R, N
FOR12A FOR12A 12 R, N
FOR12B FOR12B 12 R, N
Ammonia Vapor Compression With Secondary Loop   12, 500 N
Evaporative/Desiccant Cooling   12, 500 N
Ammonia / Water Absorption   12, 500 N
Water / Lithium Bromide Absorption   12, 500 N
THR-02 THR-02 12 N
ISCEON 39TC ISCEON 39TC 12 R, N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Centrifugal Chillers

Substitute (Name Used in the Federal Register) Trade Name Retrofit/ New
THR-03   N
ISCEON 59, NU-22, R-417 Isceon 59, NU-22 R, N
R-410A, R-410B AZ-20, Suva 9100, Puron N
R-407C Suva 9000, Klea 66 R, N
R-507, R-507A AZ-50 R, N
Ammonia Vapor Compression With Secondary Loop   N
Ammonia Absorption or Water/Lithium Bromide Absorption   N
Evaporative/Desiccant Cooling   N
R-404A HP62 R, N
R-125/134a/600a (28.1/70.0/1.9)   R, N
RS-44 RS-44 R, N
Key: R = Retrofit Uses, N = New Uses

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