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Ecosystems Research

John F. Kenneke

My research focuses on developing innovative approaches for elucidating the absorption, distribution, metabolism and elimination (ADME) of xenobiotics in organisms, and applying experimental results to understanding and modeling chemical exposure for informing human health and ecological risk assessment.  I utilize in vitro and in vivo systems from a variety of invertebrate and vertebrate species, including human, to measure xenobiotic metabolic maps, biotransformation kinetics, biotransformation mechanisms and stereo specific metabolism.  These results are used to develop physiological based pharmacokinetic models for predicting dose as a function of exposure concentration, and to extrapolate between species, routes of exposure, and from high-to-low exposure levels.  These tools directly apply to prioritizing chemicals for hazard testing and managing chemical risk.      

Biographical Information

Name: John F. Kenneke
Title: Research Chemist

Contact Information:

Ecosystems Research Division
National Exposure Research Laboratory
Office of Research and Development
U.S. Environmental Protection Agency
960 College Station Road
Athens, Georgia 30605-2700

Phone: 706-355-8247
Email: kenneke.john@epa.gov

Education

Ph.D. Environmental Chemistry, University of North Carolina, Chapel Hill, 1996
M.S. Organic Chemistry, University of Illinois, Urbana-Champaign, 1989
B.S. Chemistry and Biology, Iowa State University, 1987

Professional Experience

Research Chemist, USEPA, ORD, NERL-ERD, Athens, GA  1998-present
NRC Research Associate, USEPA, ORD, NERL-ERD, Athens, GA  1996-1998
Visiting Researcher, University of Kuopio, Finland  1995; 1997
Chemist, Triangle Laboratories, Durham, NC  1990; 1995-1996
Research Assistant, University of North Carolina, Chapel Hill, NC  1990-1995
Research/Teaching Assistant, University of North Carolina, Chapel Hill, NC  1989-1990
Analytical Chemist, Allied-Signal/Union Carbide/UOP, Des Plaines, IL  1985-1987; 1989
Research/Teaching Assistant, University of Illinois, Urbana-Champaign, IL  1987-1989

Professional Affiliations

American Chemical Society
Division of Environmental Chemistry, American Chemical Society
International Society for the Study of Xenobiotics

Invited Lectures/Symposia

Global Metabolomics of Breast Cancer Cells, Chicago Regional NMR Meeting, Chicago, IL. 2009
Cell Culture-based Metabolomics for Chemical Exposure and Toxicity, SETAC North America 32nd Annual Meeting, Portland, OR, 2010
Cell-based Metabolomics: a New Tool for Chemical Exposure and Toxicology, College of Pharmacy, University of Georgia, Athens, GA, 2011
Metabolomics Applications for Assessing Chemical Exposure and Toxicity, Department of Chemistry, Clark Atlanta University, Atlanta, GA, 2011
Cell-based Metabolomics: a New Tool to Assess Environmental Exposure and Toxicity, SETAC North America 32nd Annual Meeting, Boston, MA, 2011
Cellular Metabolomics for Assessing Chemical Exposure and Toxicity, Computational Systems Biology Laboratory, Dept of Biochemistry & Molecular Biology, University of Georgia, Athens, GA, 2012.

Selected Awards and Honors

USEPA STAA Award - Level II 2008
US EPA STAA Awards - Level III 2009, 2010
US EPA ORD Teamwork Award  2011

Publications and Presentations

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