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Ecosystems Research

Satori A. Marchitti

My research interests involve the characterization and prediction of exposure pathways from environmental contaminants in humans and ecologically important species, including the generation of ADME data and physiologically based pharmacokinetic (PBPK) models for the prioritization of chemicals of concern and risk evaluation. 

Biographical Information

Name: Satori A. Marchitti
Title: Toxicologist

Contact Info:

Ecosystems Research Division
National Exposure Research Laboratory
Environmental Protection Agency
960 College Station Road
Athens, Georgia 30605

Phone: 706-355-8259
email: marchitti.satori@epa.gov

Education

Ph.D. Toxicology, University of Colorado, Denver, 2010
B.A. Psychology, Neuroscience Interdisciplinary Certification, University of Colorado, Boulder, 2002

Professional Experience

Toxicologist, EPA/ORD/NERL/ERD, 2011-present
Adjunct Faculty, Department of Chemistry, Metropolitan State College of Denver, Denver, CO, 2011    
Post-doctoral training, Department of Pharmaceutical Sciences, University of Colorado Denver, Denver, CO, 2010
LC/MS/MS training internship, Colorado Department of Public Health and Environment, Denver, CO, 2008
Doctoral candidate, Toxicology Program, University of Colorado Denver, Denver, CO
Responsible for all laboratory operations. teaching and providing support for multiple courses, including Biochemistry and Physiology, 2003-2010
Forensic Toxicology Laboratory Technician, Ruth Forensic Lab, University of Colorado Denver, Denver, CO, 2004-2006
Graduate Research Internship, Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, 2004
Graduate Research Internship, National Jewish Medical and Research Center, Denver, CO, 2003
Professional Research Assistant Institute for Behavioral Genetics, University of Colorado, Boulder, CO, 2002-2003
Undergraduate Research Assistant, Institute for Behavioral Genetics, University of Colorado, Boulder, CO, 2000-2002

Professional Affiliations

Member: Society of Toxicology, International Society for Exposure Science
Reviewer: Environmental Science & Technology

Selected Awards and Honors

National Institutes of Health (NIH) Ruth L. Kirschstein National Research Service Award.

Predoctoral Fellowship (1F31AA016875), NIH/National Institute on Alcohol Abuse and Alcoholism (NIAAA). Title: Aldehyde Dehydrogenase 3B1 (ALDH3B1): Characterization and Role in Oxidative Stress (P.I. Satori Marchitti) $26,772 annually, May 2007-May 2010

Graduate Student Travel Award, 47th Annual Meeting of the Society of Toxicology, Seattle, WA 2008  

Graduate Student Travel Award, 3rd Annual National Graduate Student Research Festival, National Institutes of Health (NIH), Bethesda, MD 2008  

Graduate Student Travel Award, 26th Annual Meeting of the Mountain West SOT, Salt Lake City, UT 2008  

Graduate Student Travel Award, 25th Annual Meeting of the Mountain West Society of Toxicology, Breckenridge, CO 2007

Outstanding Student Poster Presentation Award, The Department of Pharmaceutical Sciences Annual Retreat, Breckenridge, CO 2006  

Publications and Presentations

Marchitti S.A., Chen Y., Thompson D.C., Vasiliou V. Ultraviolet radiation: cellular antioxidant response and the role of ocular aldehyde dehydrogenase enzymes. Eye & Contact Lens; 37(4):206-213; 2011
“Aldehyde Dehydrogenase 3B1 (ALDH3B1): Characterization and Role in Oxidative Stress”. Metropolitan State College of Denver, Denver, Colorado, USA, 2010
“Drug Metabolism and Aldehyde Toxicity: The Role of the Aldehyde Dehydrogenase Superfamily of Enzymes”. Metropolitan State College of Denver, Denver, Colorado, USA, 2010
Marchitti S.A., Orlicky D.J., Vasiliou V. Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues. J Histochem Cytochem; 9:765-783; 2010
Marchitti S.A., Brocker C., Orlicky D.J., Vasiliou V. Molecular characterization and expression analysis of ALDH3B1: role in cellular protection against oxidative damage. Free Radic Biol Med; 49:1432-43; 2010
Endo J., Sano M., Katayama T., Hishiki T., Shinmura K., Morizane S., Matsuhashi T., Katsumata Y., Zhang Y., Ito H., Nagahata Y., Marchitti S.A. et al. Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res ;105:1118-27; 2009
Black W.J., Stagos D., Marchitti S.A., Nebert D.W., Tipton K.F. et al. Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature. Pharmacogenet Genomics ;19:893-902; 2009
Marchitti S.A., Bateman B.J., Petrash J.M., Vasiliou V.  Mouse models of the cornea and lens: understanding ocular disease. In: “Animal Models for Eye Research”. P.A. Tsonis (editor), Elsevier, 2008 Aug: 143-167.
Marchitti S.A., Brocker C., Stagos D., Vasiliou V. Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily. Expert Opin Drug Metab Toxicol; 4:697-720; 2008
Marchitti S.A., Deitrich R.A., Vasiliou V. Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev; 59:125-50; 2007
Marchitti S.A., Orlicky D.J., Vasiliou V. Expression and initial characterization of human ALDH3B1. Biochem Biophys Res Commun ;356:792-8; 2007
Tritto T., McCallum S.E., Waddle (maiden name) S.A., Hutton S.R., Paylor R., Collins A.C. et al. Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia. Nicotine Tob Res ;6:145-58; 2004


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