Chris Mazur
Name: Christopher S. Mazur
Title: Research Biologist
Education:
| M.S. 1995 | Department of Zoology and Physiology/Water Resource Division. University of Wyoming, Laramie, Wy. |
| B.A. 1993 | Environmental Science/Biology (Chemistry Minor), Mansfield University, Mansfield, Pa. |
Contact Information:
Ecosystems Research Division
National Exposure Research Laboratory
U.S. Environmental Protection Agency
960 College Station Road Athens, Ga. 30605-2720
ph: (706) 355-8233 fax: (706) 355-8202
email: mazur.chris@epa.gov
Research:
Current research focuses on the in vitro metabolism of selected foreign chemicals using microsomal assays and hepatocyte cell culture techniques: development of saturation kinetic profiles, enzyme characterization, biotransformation pathway delineation using analytical techniques.
Select Publications:
Mazur, C.S., Kenneke, J.F. 2008. Cross-Species Comparison of Conazole Fungicide Metabolites Using Rat and Rainbow Trout (Onchorhynchus mykiss) Hepatic Microsomes and Purified Human CYPA 3A4. Environmental Science and Technology, 42, (3), 947-954.
Kenneke, J.F., Mazur, C.S., Ritger, S.E., Sack, T.J. 2008. Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes. Chemical Research in Toxicology, 21, 1997- 2004.
Mazur. C.S., Kenneke, J.F., Tebes-Stevens, C., Okino, M.S., and Lipscomb, J.C. 2007. In vitro metabolism of the fungicide and environmental contaminant trans- bromuconazole and implications for risk assessment. Journal of Toxicology and Environmental Health. Part A, 70:1241-1250.
Jones, W. J., Mazur, C.S., Kenneke, John F., and Garrison, A.W. 2007. Enantioselective Microbial Transformation of the Phenylpyrazole Insecticide Fipronil in Anoxic Sediments. Environmental Science and Technology, 41, (24), 8301 - 8307, 2007.
Hoehamer, C., Mazur, C.S., Wolfe, L.N. 2005. Purification and partial characterization of an acid phosphatase from Spirodela oligorrhiza and its affinity for selected organophosphate pesticides.Journal of Agriculture and Food Chemistry., 53, 90-97.
Mazur, C.S., Jones, W.J. and Tebes-Stevens, C. 2003. H2 consumption during the microbial reductive dehalogenation of chlorinated phenols and perchloroethylene. Biodegradation , 14:285-295.
Mazur, C.S. and Jones, W.J. 2001. Hydrogen concentrations in sulfate-reducing estuarine sediments during PCE dehalogenation. Environmental Science and Technology. 35, 4783-4788.
Gao, J., Garrison, W.A., Mazur, C.S., Hoehamer, C., Wolfe, L.N. 2000. Uptake and phytotransformation of organophosphorus pesticides by axenically cultivated aquatic plants. Journal of Agriculture and Food Chemistry. 48, 6114-6120.
Gao, J., Garrison, W.A., Mazur, C.S., Hoehamer, C., Wolfe, L.N. 2000. Uptake and phytotransformation of o,p’-DDT and p,p’-DDT by axenically cultivated aquatic plants. Journal of Agriculture and Food Chemistry. 48, 6121-6127.
Abstracts/Presentations:
Mazur, C.S. Kenneke, J.F. Cross-Species Comparison of Conazole Fungicide Metabolites Using Rat and Rainbow Trout (Onchorhynchus mykiss) Hepatic Microsomes and Purified Human CYP 3A4. International Society for the Study of Xenobiotics, 8th International, October, 2007, Sendai, Japan.
Kenneke, J.F., Mazur.C.S., In Vitro Metabolism Research at NERL/ERD: An Overview of the Conazole Fungicides. ORD National Center for Computational Toxicology, October 11, 2006, RTP, N.C.
Chang. D.T., Whitehead, T.L., Okino, M.S., Mazur, C.S., Kenneke, J.F., Tornero-Velez, R., Johnson, J., and Dary, C.C. An In Silico Investigation of the Enantioselective Metabolism Rates of Triazole Fungicides. International Society for the Study of Xenobiotics, 14 th N.A. October, 2006, Puerto Rico.
Mazur, C.S. and Kenneke, J.F. In vitro Metabolism of the Chiral Fungicide Bromuconazole 47 using Substrate Depletion and Product Formation Kinetics in Rat Hepatic Microsomes. International Society for the Study of Xenobiotics, 13 th N.A. October, 2005, Maui, Hawaii.
Kenneke, J.F. and Mazur,C.S. Enantioselective In Vitro Metabolism of the Triazole Fungicides Bromuconazole and Triadimefon using Rat Hepatic Microsomes. International Society for the Study of Xenobiotics, 13 th N.A. October, 2005, Maui, Hawaii.
Kenneke, J.F., Mazur, C.S., and Garrison, W.A. In vitro Phase I Metabolism of the Triazole Fungicide Bromuconazole and its Four Enantiomers. 230th ACS National Meeting, August, 2005,Washington, DC.