My current research focuses on the in vitro metabolism (ADME) of foreign chemicals using microsomal assays, hepatocyte cell cultures, transfected cell lines and vesicle assays to characterize transport and biotransformation processes.
Name: Christopher S. Mazur
Title: Research Biologist
Ecosystems Research Division
National Exposure Research Laboratory
Office of Research and Development
U.S. Environmental Protection Agency
960 College Station Road
Athens, Georgia 30605-2700
M.S. Zoology and Physiology/Water Resource Division, University of Wyoming, 1995
B.A. Environmental Science/Biology, Mansfield University, 1993
Research Biologist, USEPA, ORD, NERL-ERD, Athens, GA 1996–present
Selected Awards and Honors
USEPA, STAA Award, Level III, 2002, 2003, 2006, 2009, 2010, 2011, 2013
USEPA STAA Awards Honorable Mention 2004, 2008
University of Wyoming, Fall Teaching Assistantship Award, 1989
Oakridge Institute for Science and Education, Fellowship Award, 1996-1998
Mazur,C.S., Marchitti, S.A., Zastre, J. 2015. P-glycoprotein inhibition by the agricultural pesticide propiconazole and its hydroxylated metabolites: Implications for pesticide-drug interactions. Toxicology Letters, 232:37-45.
Mazur, C.S., Marchitti, S.A., Dimova, M., Kenneke, J.F., Lumen, A., Fisher, J. 2012. Human and rat ABC transporter efflux of Bisphenol A and Bishpenol A glucoronide: interspecies comparison and implications for pharmacokinetic assessment. Toxicological Sciences, 128:317-325
Mazur, C.S., Kenneke, J.F., Hess-Wilson, J.K., Lipscomb, J.C. 2010. Differences between human and rat intestinal and hepatic Bisphenol A glucuronidation and the influence of alamethicin on in vitro kinetic measurements. Drug Metabolism and Disposition, 38:2232-2238
Mazur,C.S., Kenneke, J.F., Goldsmith, M.R., Brown, C.C. 2009. Contrasting influence of NADPH and a NADPH-regenerating system on the metabolism of carbonyl-containing compounds in hepatic microsomes. Drug Metabolism and Disposition, 37:1801-1805.
Mazur, C.S., Kenneke, J.F. 2008. Cross-species comparison of conazole fungicide metabolites using rat and rainbow trout (Onchorhynchus mykiss) hepatic microsomses and purified CYP 3A4. Environmental Science and Technology, 42:947-954.
Mazur, C.S., J.F. Kenneke, C.T. Tebes-Stevens, M.S. Okino and J.C.
Lipscomb. 2007. In Vitro Metabolism of the Fungicide
and Environmental Contaminant trans-bromuconazole and Implications for
Risk Assessment. Journal of Toxicology and Environmental Health,
Part A. 70:1241-1250.