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Guidance for Searching for Chemical Information and Data
Introduction
Description of Selected Information Sources
IMPORTANT: The fact that a resource is included in this guide does not mean that EPA is endorsing that source. Nor does it mean that EPA will automatically accept data included in or referenced by that source. Studies and data will need to meet the requirements as spelled out in the guidance document on data adequacy in order to be accepted under the HPV Challenge Program.
The following items are provided as examples of the types of sources sponsors might wish to check. This list is provided for informational purposes only. EPA cannot guarantee that any of the sources below contain information on chemicals of interest. Even if they do EPA cannot guarantee that they contain data on any of the SIDS endpoints for a particular chemical.
Sponsors are encouraged to investigate other information sources at their discretion. Possible sources of further assistance are identified in the "Obtaining Assistance" portion of this guide.
- A chemical database produced
by the Chemical Abstracts Service (CAS)
,
a division of the American Chemical Society.
Covers all facets of chemical information, not just toxicology. Available
through STN and other vendors.
Contains data on over 2,000 organic chemicals. Would be more likely to have environmental fate data than data for other endpoints. Arranged alphabetically by chemical name. Includes a formula index.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (IARC Monographs)
- 193.51.164.11/default.html
- The IARC Monographs are
prepared by the International Agency on Research
on Cancer (IARC) http://www.iarc.fr
.
IARC is a unit of the World Health Organization (WHO). The IARC Monographs
series publishes authoritative independent assessments by
international experts of the carcinogenic risks posed to humans by a variety of agents. Since its inception
in 1972, the series has reviewed more than 800 agents,
and IARC Monographs have become well-known for their thoroughness,
accuracy and integrity.
Though carcinogenicity is
not one of the SIDS endpoints, IARC monographs could include data on some
SIDS endpoints. (If they do, those data would be subject to the same
data adequacy guidelines
as any other data submitted to the HPV Challenge Program.) For example,
a section of the Preamble to the IARC Monographs
notes that IARC has gathered (http://193.51.164.11/monoeval/Other.html") other
data considered to be relevant to an evaluation of carcinogenicity.
These can include data on acute and chronic effects (other than cancer),
as well as endocrine, reproductive, and developmental effects. Genetic
and related effects data may also be included.
- MSDS's provide basic safety
information on commercial chemicals. Manufacturers are responsible for preparing MSDS's
for their products. Companies should check the sources
they use to prepare their MSDS's to see whether they would provide adequate data for the HPV Challenge program.
Collections of MSDS's are also available from a number of vendors as well as from some Internet sites.
- Volume 2 (consisting of
six parts) of this multi-volume work discuss the toxicity of broad groupings
of chemicals, primarily within the context of industrial hygiene and occupational
health. Chapters do include data on specific chemicals when available.
Published by John Wiley & Sons.
IMPORTANT: The fact that a resource is included in this guide does not mean that EPA is endorsing those sources. Nor does it mean that EPA will automatically accept data included in or referenced by those sources. Studies and data will need to meet the requirements as spelled out in the guidance document on data adequacy in order to be accepted under the HPV Challenge Program.
Send comments on this
guide to the Chemical Right to Know
staff (oppt.chemrtk@epa.gov).