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2009 Board of Scientific Counselors Computational Toxicology Review

Note: EPA no longer updates this information, but it may be useful as a reference or resource.

2009 BOSC Documents
(PDF, 1195 pp., 33.3MB)


The National Center for Computational Toxicology (NCCT) became operational on February 20, 2005.  On April 25-26, 2005, the BOSC Computational Toxicology Subcommittee held its first public meeting at the Office of Research and Development's (ORD) Research Triangle Park (RTP), North Carolina facility, where the majority of NCCT staff is located.  This meeting was intended as the first of several consultative reviews of the Center's progress, and was prospective in nature, due to the newness of the Center.  The Subcommittee developed a letter report from the April meeting which addressed six charge questions that concentrated on the NCCT's strategic goals; its collaborations, and connectedness to the rest of the Agency and to outside scientists; its staffing plan; and its thematic choices.  The letter report was finalized by the BOSC Executive Committee and transmitted to ORD in July 2005.  A formal response of the NCCT to the review was provided to the BOSC at their September 2005 Executive Committee meeting. 

The Subcommittee met again in a June 2006 review to continue to provide the NCCT with advice on the progress the Center had made, since Spring 2005, in fulfilling its mission and strategic goals.  The subcommittee addressed nine charge questions, which touched on the new extramural bioinformatics centers, effectiveness of Center work in Agency research, use of computational tools, feedback on the first generation computational toxicology implementation plan, effectiveness of Center communication of research, outcomes, and responsiveness to stakeholder needs.  A letter report was finalized by the BOSC Executive Committee and transmitted to ORD in December 2006.  A formal response of the NCCT to the review was provided to the BOSC at their January 2007 Executive Committee meeting. 

In December 2007, the Subcommittee met to discuss progress the NCCT had made with respect to five NCCT activities: ToxCast™; Information Management/Information Technology (IM/IT) - Informatics; Virtual Liver; Developmental Systems Biology; and Arsenic Biologically-Based Dose Response Model.  A letter report was finalized by the BOSC Executive Committee and transmitted to ORD in September 2008.  A formal response of the NCCT to the review was provided to the BOSC at their February 2009 Executive Committee meeting.  That response included more details on progress with informatics (ACToR, DSSTox, ToxRefDB), chemical prioritization (ToxCast and ExpoCast), and systems modeling (v-Liver™ and v-Embryo™); and an explanation of the disinvestment in arsenic research. 

September 2009 Review

The purpose of the September 2009 review is to provide the NCCT and broader ORD Computational Toxicology Research Program (CompTox) with 1) advice/recommendations on the progress the CompTox has made in the past four and a half years in fulfilling its mission and strategic goals; and 2) advice/recommendations on whether the NCCT should continue as an established organization beyond its original five-year charter. In particular, the subcommittee will address the following questions:

  • Charge Question 1: What is your evaluation of the progress the CompTox has made in achieving its original goals and objectives, and whether it has efficiently utilized available resources?
  • Charge Question 2: To what extent and how effectively has the CompTox utilized internal and external partnerships to foster its goals?
  • Charge Question 3: What evaluation can you provide relative to the contributions of the CompTox to the advancement of transforming the field of toxicity testing?
  • Charge Question 4: To what extent do the ORD intramural projects, the extramural STAR centers, and the five stated CompTox management priorities described in the FY09-12 implementation plan combine to efficiently support the goal of providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk to human health?
  • Charge Question 5: The NCCT was established as an organization with a five-year charter ending in February 2010, which would continue dependent on: 1) meeting established goals; and 2) having continuing mission-critical goals and objectives. What recommendation(s) can you provide the Agency regarding continuation of the NCCT as an established organization, and the criticality of its goals and objectives to EPA?

For more information about the EPA BOSC Program please visit www.epa.gov/osp/bosc/index.htm


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  Poster Title Presenter
Session 1
  1 ACToR: Aggregated Computational Toxicology Resource R Judson
  2 DSSTox and Chemical Information Technologies in Support of Predictive Toxicology A Richard
  3 Characteristics and Applications of the ToxRefDB In Vivo Datasets from Chronic, Reproductive and Developmental Assays M Martin
  4 Literature Mining and Knowledge Discovery Tools for Virtual Tissues A Singh
  5 ExpoCast: Exposure Science for Prioritization and Toxicity Testing E Cohen Hubal
  6 Computational Approaches and Tools for Exposure Prioritization and Biomonitoring Data Interpretation C. Tan
  7 Advanced Exposure Mertics for Chemical Risk Aanalysis T. Collette
  8 The U.S. "Tox21 Community" and the Future of Toxicology  R Tice (NTP/NIEHS)
  9 Supported STAR Research Centers Advance the Field of Computational Toxicology D Segal (NCER)
  10 UNC The Carolina Environmental Bioinformatics Center F Wright (UNC)
  11 UMDNJ Environmental Bioinformatics & Computational Toxicology Center (ebCTC): Research Collaborations in Multi-Scale Modeling of Environmental Toxicants B Welsh (UMDNJ)
  12 UNC Systems Biology - Carolina Center for Computational Toxicology I Rusyn (UNC)
  13 UTH - The Texas-Indiana Virtual STAR Center; Data-Generating in vitro and in silico Models of Developmental Toxicity in Embryonic Stem Cells and Zebrafish Eva M. Bondesson (UTH)
  14 Mechanistic Indicators of Childhood Asthma (MICA): A Systems Biology Approach for the Integration of Multifactorial Environmental Health Data J Gallagher (NHEERL)
  15 Linkage of Exposure and Effects Using Genomics, Proteomics, and Metabolomics in Small Fish Models T Collette for G. Ankley (NERL)
  16 Development of a Searchable Metabolite Database and Simulator of Xenobiotic Metabolism J Jones (Athens)
  17 Risk Assessment of the Inflammogenic and Mutagenic Effects of Diesel Exhaust Particulates: A Systems Biology Approach J Samet (NHEERL)
  18 Development of Microbial Metagenomic Markers for Environmental Monitoring Jorge W. Santo Domingo (NERL)
  19 Develop a Systems Approach to Characterizing and Predicting Thyroid Toxicity Using an Amphibian Model S Degitz (NHEERL)
Session 2
  1 Bioactivity Profiling Results from ToxCast Phase I Assays K Houck
  2 ToxMinerTM Software Interface for Visualizing and Analyzing ToxCast Data M. Martin
  3 Evaluating the Toxicity Pathways Using High-Throughput Environmental Chemical Data H Mortensen
  4 Modeling and Predicting Cancer from ToxCast Phase I Data R Judson
  5 Endocrine Profiling Prioritization Using ToxCast Assays D Reif
  6 Computational Molecular Modeling Methods for Screening for Chemical Toxicity: The Toxicant-Target Approach J Rabinowitz
  7 Development of high throughput methods for chemical screening and prioritization W Mundy et al (NHEERL)
  8 The Second Phase of ToxCast and Initial Applications to Chemical Prioritization D. Dix
  9 Nuclear Receptor Activity and Liver Cancer Lesion Progression I Shah
  10 A Virtual Liver for Simulating Chemical-Induced Injury J Wambaugh
  11 Experimental Models for Quantitative Analysis of Hepatocarcinogenesis Chris Corton (NHEERL)
  12 EPA'S Virtual Embryo: Modeling Developmental Toxicity T Knudsen
  13 Predictive Modeling of Developmental and Reproductive Toxicity Pathways Hunter et al
  14 Adaptive Responses to Prochloraz Exposure that Alter Dose-Response and Time-Course Behaviors R Conolly
  15 Applying Uncertainty Analysis to a Risk Assessment for the Pesticide Permethrin R Setzer
  16 Methodology for Uncertainty Analysis of Dynamic Computational Toxicology Models J Davis



Tuesday, September 29, 2009
12:00 p.m. – 12:30 p.m. Registration
12:30 p.m. – 12:40 p.m. Welcome and Introductions
- New Subcommittee Member
- Draft Charge
- Meeting Agenda
Dr. George Daston, Subcommittee Chair
12:40 p.m. – 12:45 p.m. DFO Remarks Lori Kowalski, Office of Research and Development (ORD)
12:45 p.m. – 1:00 p.m. Computational Toxicology Research Program (CompTox) - Critical Component of EPA Science in the 21st Century Mr. Lek Kadeli, ORD Acting Assistant Administrator (AA)
1:00 p.m. – 1:45 p.m. CompTox Overview Dr. Robert Kavlock, Director, Computational Toxicology Research Program
1:45 p.m. – 2:15 p.m. Introduction to Poster Session I: Informatics, Exposure Science, ORD, and External Partners Dr. Ann Richard, NCCT
2:15 p.m. – 4:15 p.m. Poster Session I Subcommittee/ORD
4:15 p.m. – 5:15 p.m. Poster Session I: Discussion Subcommittee/ORD
5:15 p.m. – 6:15 p.m.

Comments on the CompTox
- Dr. Peter Preuss
- Mr. Jim Jones
- Dr. John Bucher
- Dr. Cal Baier-Anderson

Dr. Peter Preuss, Director, ORD/National Center for Environmental Assessment; Mr. Jim Jones, Deputy AA, EPA/Office of Prevention, Pesticides, and Toxic Substances; Dr. John Bucher, Associate Director, National Toxicology Program, National Institutes of Health; Dr. Cal Baier-Anderson, Senior Health Scientist, Environmental Defense Fund
6:15 p.m. Adjourn
Wednesday, September 30, 2009
8:00 a.m. – 8:30 a.m. Introduction to Poster Session II: High Throughput Screening, Toxicity Predictions, Virtual Tissues, and Uncertainty Analysis Dr. Thomas Knudsen, NCCT
8:30 a.m. – 10:30 a.m. Poster Session II Subcommittee/ORD
10:30 a.m. – 11:30 a.m. Poster Session II: Discussion Subcommittee/ORD
11:30 a.m. – 12:00 noon CompTox Future: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard, and Risk Dr. David Dix, Acting Deputy Director, NCCT
12:00 noon – 12:15 p.m. Public Comment  
12:15 p.m. – 1:15 p.m. Working Lunch Subcommittee
1:15 p.m. – 3:30 p.m. Subcommittee Working Time Subcommittee
3:30 p.m. Adjourn

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