Computational Toxicology Research Program
Semi-Volatile Organic Compounds Indoor Environment Workshop
Who: Indoor Air Institute, EPA’s National Center for Computational Toxicology and National Exposure Research Lab, ACC LRI and EPA Indoor Environment
What: SVOCs in the Indoor Environment: Mechanistic Insights to Support Sustainable Product Design, Safe Use and Improved Public Health Workshop
When: January 5-7, 2011
Where: Research Triangle Park, North Carolina
Why: Workshop objectives include:
- Interrogate and generalize the framework proposed in 2009 SVOC Workshop by considering a broad range of SVOCs to demonstrate the extent to which mechanisms along the source-to-dose continuum are controlled by physical/chemical properties of the SVOCs or their metabolites;
- Consider extension of framework for a holistic systems-based approach that enables relevant processes to be linked across the source-to-dose continuum, adjusting the scales of the various mechanistic processes so that these can be appropriately integrated;
- Consider extension of framework to evaluate potential exposures across the product lifecycle for all chemical classes and for all use scenarios to inform design, evaluation and risk management;
- Propose screening-level, rapid exposure assessment approaches based on simplified forms of mechanistic exposure models.
Workshop outcomes will include a summary of key concepts as well as research needs identified during the presentations and facilitated discussions.