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EDRI Federal Project Inventory:
52656-05 Changing Epidemiology of Thyroid Cancer
- Sponsor Organization: NIH/NCI
- Project Title: 52656-05 CHANGING EPIDEMIOLOGY OF THYROID CANCER
- Project Focus: HUMAN HEALTH EFFECTS, EXPOSURE ASSESSMENT
- Description: While rates of thyroid cancer among men have declined during the 1970s
and 1980s in western Washington, ratesamong women have increased. The
increase in incidence is particularly marked for women aged 35-54, in
whom rateshave nearly doubled from 1974-1987. Exposure to childhood
irradiation of the head and neck (the principal establishedrisk factor
for thyroid cancer) seems unlikely to fully account for these
observations, given the declining prevalence ofthis exposure among
women in this age group. Previous studies suggest that hormonal
factors, such as use of exogenousestrogens, parity and hormonal
abnormalities associated with miscarriage and infertility may increase
risk of thyroidcancer. However, these earlier studies may have
considerably underestimated risk associated with oral contraceptive
usedue to inadequate opportunity for exposure, inadequate years of
elapsed latent period, or greater prevalence of radiation-induced
cancers. We propose a population-based case-control study of thyroid
cancer among women in three countiesof western Washington to test the
hypothesis that oral contraceptive use, particularly that occurring
early in life or forlong time periods, may increase risk of thyroid
cancer. All white female residents of King, Pierce, and
SnohomishCounties aged 18-64 years and diagnosed with incident
thyroid cancer of the follicular epithelium from January 1,
1988through June 30, 1995 will be identified and invited to
participate in the study. Cases will be identified through theCancer
Surveillance System (CSS), a population-based tumor registry that has
served the area since 1974. Controls willbe selected-by random digit
dialing and will be frequency matched to cases on age (by five-year
intervals) and county ofresidence. Cases and controls will be
interviewed in person regarding their use of oral contraceptives and
otherexogenous estrogens, as well as reproductive and menstrual
history, history of infertility and other known or suspectedrisk
factors for thyroid cancer.
- References:
- Category: MEASUREMENTS
- Subcategory: EXPOSURE AND RISK MODELS
- Keywords for Experimental System/Species: HUMAN, FIELD STUDY
- Keywords for Experimental Endpoints: FEFEMALE, HORMONAL MEASURES, THYROID HORMONES, EXPOSURE MONITORING,
REPRODUCTIVE, RISK FACTORS
- Chemical Agents: EXOGENOUS ESTROGEN, ORAL CONTRACEPTIVES
- Performing Institution: FRED HUTCHINSON CANCER RESEARCH CENTER
- Contact: CONTACT PERSON:ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301 496-5515;
LEEE@0D.NCI.NIH.GOV
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