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EDRI Federal Project Inventory:
54419-04 Ovarian Cancer Risk and Hypergonadotropic Hypogonadism
- Sponsor Organization: NIH/NCI
- Project Title: 54419-04 OVARIAN CANCER RISK AND HYPERGONADOTROPIC HYPOGONADISM
- Project Focus: HUMAN HEALTH EFFECTS
- Description: Experimental and epidemiologic evidence suggests human ovarian cancer
is caused by hypergonadotropichypogonadism (high gonadotropins
consequent to failing ovaries). To identify risk factors linked to
ovarian cancer thruthis model, a population based case-control study
is proposed using 650 ovarian cancer cases newly diagnosed in
threeNortheast Massachusetts counties and the state of New Hampshire
and using age and residence matched controlsselected via random digit
dialing. Data will be obtained thru personal interview, a self-
administered dietaryquestionnaire, and blood collection. Key
variables possibly linked to hypogonadism and ovarian cancer are
highgalactose consumption and deficient galactose metabolism. The use
of galactose rich foods will be assessed andanalyzed in perspective of
the subject's ability to metabolize galactose. Biochemical activity
of three key enzymes willbe determined (galactokinase, galactose-1
phosphate uridyl transferase, and uridine diphosphogalactose-4-
epimerase). Other exposures possibly linked to hypogonadism to be
assessed include smoking, caffeine, and tannic acidconsumption.
Reproductive variables, oral contraceptive (OC) use, and talc exposure
will also be assessed to determinetheir interrelationship with the
environmental and biochemical risk factors, particularly, whether the
effect of oocytetoxins on ovarian cancer risk is more apparent among
women who have never used OC's. As a secondary aim we willcreate a
serum and buffy coat bank to permit a search for DNA markers possibly
related to ovarian cancer includinggenetic alterations related to the
locus for galactose transferase or to p53 which we speculate may
indirectly relate togalactose metabolism, or via an alternate cause of
hypogonadism involving chromosome deletions in the region Xq21-27.
Knowledge of genetic biochemical, and environmental factors associated
with ovarian cancer thruhypergonadotropic hypogonadism has public
health importance in devising strategies for prevention of this
disease. Therole of galactose rich foods in ovarian cancer etiology
is particularly important because of a substantial increase in theuse
of these foods in the United States.
- References:
- Category: MEASUREMENTS
- Subcategory: EXPOSURE AND RISK MODELS
- Keywords for Experimental System/Species: HUMAN, FIELD STUDY
- Keywords for Experimental Endpoints: EXPOSURE MONITORING, CARCINOGENESIS, RISK FACTORS, EPIDEMIOLGOY
- Chemical Agents: TANNIC ACID, ORAL CONTRACEPTIVES, OOCYTE TOXINS, CAFFEINE
- Performing Institution: BRIGHAM AND WOMEN'S HOSPITAL
- Contact: CONTACT PERSON:ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301 496-5515;
LEEE@0D.NCI.NIH.GOV
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