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EDRI Federal Project Inventory:
62912-03 DES and Cancer of Vagina/Cervix–Collaborative Studies
- Sponsor Organization: NIH/NCI
- Project Title: 62912-03 DES AND CANCER OF VAGINA/CERVIX--COLLABORATIVE STUDIES
- Project Focus: HUMAN HEALTH EFFECTS
- Description: The data which are collected and analyzed in the Registry provide the
sole comprehensive series of cases of DES-associated clear cell
adenocarcinoma (CCA) for comparative and collaborative study. The
specific aims are to updateand enhance the data on currently
accessioned cases of CCA; to maximize ascertainment of newly diagnosed
cases; toadd to the Registry women who have been treated but not
previously accessioned, by collaborating with the DES CancerNetwork
(DCN - Collaborative Project A); to monitor the development of other
mullcrian-derived primary cancers,such as cancer of the fallopian tube
and endometrium to detect early any increase in occurrence; to serve
as a source ofinformation for treating physicians and patients; and
to serve as a collaborating resource with NCI for other
approvedinvestigators who will rely on the Registry participants
and/or data for research implementation. Once an expandedcohort has
been established by adding all identify new cases of documented CCA, a
questionnaire (approved by theProject Steering Committee) will be
applied to all study participants. This questionnaire will
incorporate new data forRegistry as well as for the collaborating
investigations. Additional topics to be investigated include
extension of the age-incidence curve of CCA to older patients,
updating the survival curve and investigation of factors affecting
survival andrecurrence including the complications of therapy. A
collaborative trial through NCI will be sought to develop animproved
regimen for recurrence therapy. Two additional collaborative projects
are proposed. The first is a case-controlstudy undertaken to assess
risk factors for CCA among women exposed to DES, in particular, to
assess the relation oforal contraceptive use, age at menarche, height,
obesity, and season of birth. In addition, epidemiologic factors
that maypromote recurrence of CCA, in particular, the relation of
height, obesity, cigarette smoking, and estrogen replacementtherapy
will be investigated, with emphasis on factors that may contribute to
the development of late (greater than 8years) recurrences. The second
study will be to determine if human papillomavinus and p53 tumor
suppressor genealterations, currently linked to the natural history
of non-clear cell carcinoma of the vagina and cervix, and
associatedwith CCA.
- References:
- Category: MEASUREMENTS
- Subcategory: EXPOSURE AND RISK MODELS, BASIC RESEARCH
- Keywords for Experimental System/Species: HUMAN
- Keywords for Experimental Endpoints: RISK FACTORS, CARCINOGENESIS
- Chemical Agents: DES, ORAL CONTRACEPTIVES
- Performing Institution: UNIVERSITY OF CHICAGO
- Contact: CONTACT PERSON: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301- 496-5515;
LEEE@OD.NCI.NIH.GOV
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