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EDRI Federal Project Inventory:
62984-03 Environmental Risk Factors and Breast Cancer in the NHS
- Sponsor Organization: NIH/NCI
- Project Title: 62984-03 ENVIRONMENTAL RISK FACTORS AND BREAST CANCER IN THE NHS
- Project Focus: HUMAN HEALTH EFFECTS
- Description: We propose to prospectively study four major hypotheses which may
explain regional variations in breast cancerincidence in the U.S.
These hypotheses are: 1. That levels of DDE (a metabolite of DDT) and
PCBs are higher instored blood specimens from women who develop breast
cancer compared with women who do not develop breastcancer. 2. That
some or all of the regional differences in breast cancer incidence in
a large multi-state cohort can beexplained by regional differences in
prevalence of reproductive and dietary risk factors. 3. That high
exposure toelectromagnetic fields, specifically regular sleeping on an
electric blanket, is associated with increased risk of breastcancer.
4. That vitamin D levels in the stored blood of women who develop
breast cancer are lower than in women whodo not. To accomplish this
we will utilize prospective data from 121,700 women followed since
1976 in the Nurses'Health Study, and perform nested case-control
studies based in the cohort of 33,000 women from whom we obtained
among 430 women expected to develop breastcancer after giving us a
blood sample and before June 1,1996, and compare these with these
levels among 430 controlsmatched on year of birth and month of blood
return. Similarly, we will analyze these specimens for 25-
HydroxyvitaminD, the major circulating metabolite of vitamin D. In
1992 we enquired about electric blanket use, an important source
ofexposure to EMF, and implicated in breast cancer etiology in a
previous case-control study, and we will study thisexposure
prospectively. In four years of follow-up we expect 1,652 cases to
occur which will give us ample power toexamine this issue. We will
study regional variations in the incidence and mortality of breast
cancer prospectively fromthe start of the study in 1976. We will
examine the prevalence of specific risk factors, including screening
behavior, in each region, and control for these risk factors to
assess the extent to which they explain regional variations in
incidenceand mortality.
- References:
- Category: METHODS
- Subcategory: EXPOSURE AND RISK MODELS
- Keywords for Experimental System/Species: HUMAN, FIELD STUDY
- Keywords for Experimental Endpoints: CARCINOGENESIS, EXPOSURE MONITORING, REPRODUCTIVE, EPIDEMIOLOGY,
TISSUE RESIDUE
- Chemical Agents: PCBs, DDT
- Performing Institution: BRIGHAM AND WOMEN'S HOSPITAL
- Contact: CONTACT PERSON: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301- 496-5515;
LEEE@OD.NCI.NIH.GOV
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