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Endocrine Disruptor Research Initiative
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EDRI Federal Project Inventory:
62988-03 Environmental Factors and Breast Cancer Risk in Maryland


  1. Sponsor Organization: NIH/NCI

  2. Project Title: 62988-03 ENVIRONMENTAL FACTORS AND BREAST CANCER RISK IN MARYLAND

  3. Project Focus: HUMAN HEALTH EFFECTS

  4. Description: Investigations of potential gene-environment interactions may improve our understanding of the etiology of breastcancer, a disease where less than 30 to 40107f cases can be attributed to known risk factors. The objective of thisproposal is to examine the influence of exogenous carcinogenic exposures (organochlorine compounds), a potentialsusceptibility factor (Glutathione S Transferase (GSTM1 genotype), and protective factors (antioxidants) on the risk ofbreast cancer. The proposed study will have a nested case-control design. Serum collected in 1974 (CLUE I cohort)and 1989 (CLUE II cohort) will be assayed for organochlorine compounds and antioxidant nutrients and GSTM1genotyping will be done using the buffy coat collected in 1989. Results for the 341 persons who have developed breastcancer after donating blood will be compared with 341 matched controls. Independent and interactive effects of thesefactors on the risk of breast cancer will be examined. From the viewpoint of etiology, findings will aid in understandingthe contribution of environmental organochlorine compound exposure to the development of breast cancer and thepotential inherited susceptibility to the effects of these compounds. From the viewpoint of prevention, the modifyingeffects of antioxidants on the association between organochlorine compounds and breast cancer deserve particularattention since these are factors that are amenable to practical preventive measures.

  5. References:

  6. Category: MEASUREMENTS

  7. Subcategory: EXPOSURE AND RISK MODELS

  8. Keywords for Experimental System/Species: HUMAN, FIELD STUDY

  9. Keywords for Experimental Endpoints: CARCINOGENESIS, EXPOSURE MONITORING, RISK FACTORS, EPIDEMIOLOGY

  10. Chemical Agents: ORGANOCHLORINE COMPOUNDS

  11. Performing Institution: JOHNS HOPKINS UNIVERSITY

  12. Contact: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301- 496-5515; LEEE@OD.NCI.NIH.GOV

 

 
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