|
 |
|
EDRI Federal Project Inventory:
62995-03 Environmental and Genetic Determinants of Breast Cancer
- Sponsor Organization: NIH/NCI
- Project Title: 62995-03 ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER
- Project Focus: EXPOSURE ASSESSMENT
- Description: Proposed here is a study of the role of total PCBs, individual PCB
congeners, DDT and mirex in the etiology ofpostmenopausal breast
cancer. Serum levels of these environmental contaminants will be
evaluated. In addition, theassociation with risk of genetic
polymorphisms of enzymes involved in carcinogen metabolism and
detoxification (thecytochrome P450 enzymes CYP2D6 and CYP1A1, and
glutathione-S-transferase) will be examined. Finally,
effectmodification of the association of the environmental
contaminants with risk by the genetic polymorphisms will beassessed.
This study will use stored, frozen (-70 degrees C) blood specimens
collected as part of a larger case-controlstudy of diet, reproductive
and other factors in risk of postmenopausal breast cancer. Cases (n=
150) have primary,histologically confirmed disease. Population
controls (n= 150) will be matched to cases on age and date of blood
drawand frequency matched to cases on other breast cancer risk factors
other than family history of breast cancer. New bloodsamples will be
drawn for the DNA determinations. Interview data have already been
collected on predisease usual diet,medical history, reproductive
history and family history of cancer. This study provides an important
opportunity forefficient examination of potentially important
environmental contaminants in conjunction with evaluation of
geneticsusceptibility and other known risk factors, in the
northeastern U.S., a geographic region at high risk of breast cancer.
- References:
- Category: MEASUREMENTS
- Subcategory: EXPOSURE AND RISK MODELS
- Keywords for Experimental System/Species: HUMAN, FIELD STUDY
- Keywords for Experimental Endpoints: CARCINOGENESIS, CYTOCHROME P450, REPRODUCTIVE, EPIDEMIOLOGY
- Chemical Agents: PCBs, DDTs
- Performing Institution: STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Contact: CONTACT PERSON: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301- 496-5515;
LEEE@OD.NCI.NIH.GOV
|
|
