EDRI Federal Project Inventory:
63550-01a1 NonHodgkins Lymphoma–Hair Dye and Other Exposures
- Sponsor Organization: NIH/NCI
- Project Title: 63550-01A1 NONHODGKINS LYMPHOMA--HAIR DYE AND OTHER EXPOSURES
- Project Focus: HUMAN HEALTH EFFECTS
- Description: The rapid temporal increase in the rates of non-Hodgkin's lymphoma
(NHL) suggests there are environmentaldeterminants of the disease, but
presently known risk factors can account for only a modest percentage
of the increase. A case-control study among women is proposed to
investigate several etiologic hypotheses bearing on the
increasingrates. Particular emphasis will be placed upon the history
of hair-dye use, since four recent studies have suggested
anassociation with NHL but had significant limitations. It is also
planned to investigate exposures to pesticides, organicsolvents, and
certain medications (e.g., anti inflammatory, immunosuppressive ,
beta-blockers) as risk factors for thesecancers. The rationale for
selection of the chemical/drug exposures to investigate is based upon
suggestions from priorstudies of an NHL association and indications
that the agent affects beta-cell or T-cell proliferation or function.
This willbe a population-based case-control study in upstate New York
State among women of ages 20-79 and will includeincident cases of NHL
found in a three-year period. Because of the high mortality rates for
NHL, a fast-reportingsystem will be instituted in order to interview
the cases soon after diagnosis. A histopathological review will
beconducted to confirm the case diagnoses and classify the NHL
subtypes. It is anticipated that about 600 cases of NHLwill be
included in the study. For comparison purposes, controls will be
selected from the Department of Motor Vehiclefiles (ages less 65) or
from the Health Care Financing Administration (Medicare) files (ages
more 65) or from the HealthCare Financing Administration (Medicare)
files (ages more 65). A telephone interview will be used to
obtaininformation on the risk factors and exposures of interest along
with basic sociodemographic information. The hair-dyeand other
exposure data will be analyzed for total NHL and for several
histopathologic subcategories of NHL. Exposureresponse relationships
will be examined with respect to hair dye and other exposures. This
study will have goodstatistical power to test hypotheses about the
etiology of non-Hodgkin's lymphoma and to provide relatively
preciseestimates of relative risk.
- References:
- Category: METHODS
- Subcategory: EXPOSURE AND RISK MODELS
- Keywords for Experimental System/Species: HUMAN, FIELD STUDY
- Keywords for Experimental Endpoints: EXPOSURE MONITORING, RISK FACTORS, CARCINOGENESIS
- Chemical Agents: PESTICIDES, ORGANIC SOLVENTS
- Performing Institution: NEW YORK UNIVERSITY
- Contact: CONTACT PERSON: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301- 496-5515;
LEEE@OD.NCI.NIH.GOV
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