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EDRI Federal Project Inventory:
66201-02 Environment and Breast Cancer Program
- Sponsor Organization: NIH/NCI
- Project Title: 66201-02 ENVIRONMENT AND BREAST CANCER PROGRAM
- Project Focus: HUMAN HEALTH EFFECTS, EXPOSURE ASSESSMENT
- Description: Although a substantial amount of research has been conducted on the
determinants of breast cancer andenvironmental influences on cancer
generally, there has been remarkably little effort to address
environmentaldeterminants of breast cancer. Starting with successful,
independent research programs in breast cancer andenvironmental
epidemiology, we propose to join the two though development of a team
of committed investigators andset of interrelated projects. The two
environmental agents of greatest potential importance in the etiology
of breastcancer based on available theoretical, experimental, and
epidemiologic evidence and pesticides, particularly
persistentchlorinated hydrocarbon compounds, and electromagnetic
fields. In addition, genetic polymorphisms in carcinogen-metabolizing
enzymes have been found to modify the effect of environmental
exposures on lung and bladder cancer andmay modify the effect of
pesticides on breast cancer as well. We propose to hold a workshop
with a small number ofoutside experts on electromagnetic fields and
breast cancer. We plan a series of two pilot projects on this topic.
Conducting these pilot projects over the four- year funding period
would provide critical experience and pilot data todesign and complete
successfully and full-scale epidemiologic studies to address the role
electromagnetic fields in breastcancer etiology. A determination of
whether these complex agents contribute to the etiology of breast
cancer will onlybe achieved through merging the talents and methods of
capable researchers in both environmental and breast
cancerepidemiology. These efforts will culminate in a team of
collaborating researchers with interests and experience instudying
breast cancer and the environment, along with graduate students and
postdoctoral fellows who share thoseinterests through the activities
proposed in this application, we will develop the infrastructure to
address a wide range ofpotential environmental contributors to breast
cancer etiology with the most sophisticated techniques of
bothenvironmental and breast cancer epidemiology.
- References:
- Category: METHODS
- Subcategory: MULTIDISCIPLINARY RESEARCH
- Keywords for Experimental System/Species: HUMAN, FIELD STUDY
- Keywords for Experimental Endpoints: CARCINOGENESIS, EXPOSURE MONITORING, EPIDEMIOLOGY
- Chemical Agents: PESTICIDES
- Performing Institution: UNIVERSITY OF NORTH CAROLINA CHAPEL HILL
- Contact: CONTACT PERSON: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301- 496-5515;
LEEE@OD.NCI.NIH.GOV
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