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EDRI Federal Project Inventory:
66572-01 Breast Cancer and the Environment on Long Island
- Sponsor Organization: NIH/NCI
- Project Title: 66572-01 BREAST CANCER AND THE ENVIRONMENT ON LONG ISLAND
- Project Focus: HUMAN HEALTH EFFECTS
- Description: Recently, several studies suggest that certain environmental
exposures, primarily some organochlorines, effectestrogen production
under laboratory conditions, increase mammary tumors in animals, and
many increase a woman'srisk of breast cancer. Possible route through
which organochlorine compounds (OCC) may effect breast cancer
riskinclude estrogen metabolism. Further studies have linked
residence near hazardous waste sites or chemical facilitieswith breast
cancer risk. Although the exact exposures have not been identified,
putative agents derived from suchexposures may include polycyclic
aromatic hydrocarbons (PAH), ubiquitous mammary carcinogens that are
estrogenicin some in vitro test systems. The primary aim of the
proposed study is to determine whether OCC (DDE, PCBs,chlordane) and
PAH are associated with breast cancer risk among Long Island women.
This investigation will be a five-year, population-based case-control
study. Cases will be residents of Nassau and Suffolk counties who are
newlydiagnosed with primary breast cancer during a 12-month period.
Cases will be identified through review of pathology/cytology records.
Population-based controls will be frequency matched to cases by 5-
year age groups, and identifiedusing random digit dialing and the
Health Care and Finance Administration rosters. Completed in-home
interviews areexpected for 80106f eligible subjects (1,623 cases and
1,623 controls). About 60111f all respondents are expected toprovide
biologic specimens; for cases, specimens will be collected prior to
treatment, whereas for controls, specimenswill be obtained at the
interview. Home samples of water, soil, and dust will also be
collected among women who haveresided in their homes for 15 years or
longer. A random sample of blood and urine samples from 400 cases and
400counts will be analyzed. Laboratory analyses include determination
of OCC in blood, PAH-DNA adduct, and urinarymarkers of estrogen
metabolism. The 650 home samples of soil, water, and dust will be
assayed for pesticides and PAH. For all respondents, historic
environmental exposure to these compounds will also be calculated
using geographicmodeling techniques, as well as self-reports of
occupational and residential exposure. To estimate the
associationbetween breast cancer and exposure to OCC or PAH, adjusted
odd; ratios and corresponding confidence intervals willbe calculated
using standard statistical methods. Effect modification by estrogen or
carcinogen metabolism, and otherfactors will be explored where
possible. The effect of established and suspected risk factors on
breast cancer risk amongLong Island women will also be assessed.
- References:
- Category: METHODS
- Subcategory: HAZARD IDENTIFICATION
- Keywords for Experimental System/Species: HUMAN, FIELD STUDY
- Keywords for Experimental Endpoints: EXPOSURE MONITORING, RISK FACTORS,CARCINOGENESIS
- Chemical Agents: PCBs, PAH, ORGANOCHLORINE COMPOUNDS, PESTICIDES
- Performing Institution: COLUMBIA UNIVERSITY NEW YORK
- Contact: CONTACT PERSON: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301- 496-5515;
LEEE@OD.NCI.NIH.GOV
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