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EDRI Federal Project Inventory:
04411-19 Cancer and Related Conditions in Domestic Animals–Epidemiologic Comparisons
- Sponsor Organization: NIH/CP
- Project Title: 04411-19 CANCER AND RELATED CONDITIONS IN DOMESTIC ANIMALS--
EPIDEMIOLOGICCOMPARISONS
- Project Focus: HUMAN HEALTH EFFECTS
- Description: The veterinary studies area conducts investigations using veterinary
morbidity and mortality data from universityteaching hospitals in
North America, the Armed Forces Institute of Pathology, NCI's Registry
of Experimental Cancers,and other sources. These studies investigate
the role of genetic and environmental factors on the etiology of
cancer inanimals and generate hypotheses for testing in companion
humans and other human populations. Major areas of interestinclude
the effects of household exposure to pesticides among pet dogs and
their companion humans, and studies ofcancer and other conditions
among U.S. military working dogs (MWD) who served in Vietnam relative
to that amongother MWDs who served elsewhere, with linkeage to health
conditions that occurred among their human handlers(N=20,000). Other
studies of the effects of the Vietnam experience are being conducted
using a cohort of WestVirginia residents who served in Vietnam
(N=41,000) relative to the health experience among those who
servedelsewhere (N=42,000). Previous work has shown a significant
twofold excess of Vietnam service and testicular canceramong human
patients seen collectively at three Washington, D.C. area hospitals.
Current work shows a significantassociation of testicular seminoma and
ever service in I Corps, the Combat Tactical Zone where the highest
elevations ofrisk have been identified within Vietnam among various
human studies. Further, benign prostatic hyperplasia likewiseis
significantly elevated among Vietnam service MWDs, particularly among
those who served in I Corps; canineprostatic carcinoma also is
significantly associated with Vietnam service.
- References:
- Category: MEASUREMENTS, METHOD
- Subcategory: HAZARD IDENTIFICATION, EXPOSURE DETERMINATIONS/FOLLOWUP
- Keywords for Experimental System/Species: HUMAN, MAMMALIAN (DOG)
- Keywords for Experimental Endpoints: EXPOSURE MONITORING, CARCINOGENESIS
- Chemical Agents: PESTICIDES
- Performing Institution: NCI INTRAMURAL PROGRAM
- Contact: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER INSTITUTE,
NIH,BETHESDA, MD 20892-2590; 301- 496-5515; LEEE@OD.NCI.NIH.GOV
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