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EDRI Federal Project Inventory:
04480-20 Studies of Occupational Cancer
- Sponsor Organization: NIH/CP
- Project Title: 04480-20 STUDIES OF OCCUPATIONAL CANCER
- Project Focus: HUMAN HEALTH EFFECTS
- Description: The Occupational Studies Section conducts epidemiologic studies to
identify and quantify occupational and othercauses of cancer. During
the past year a study of pesticide applicators found excesses of lung
and brain cancer. Inanother study, brain cancer was associated with
occupational exposure to methylene chloride and risks rose
withincreasing probability and level of exposure. Brain cancer was
also elevated among Chinese women exposed topesticides. Multiple
myeloma and non-Hodgkin's lymphoma was elevated among Nebraska women
living on farms whoreported mixing/applying pesticides. Bladder and
lung cancer were excessive among Russian workers exposed to beta-
napthtylamine and benzidine. In a study from the northeastern U.S.,
bladder cancer was elevated among workers in theleather and textile
industries. In a study of Chinese workers, benzene was found to cause
genetic damage bychromosomal aberration rather than point mutation.
Prostate cancer rates are known to be higher in the southeasternU.S.
than in other regions. A death certificate study found that about 40
of this excess could be explained by pastemployment in agriculture.
Proceedings from an international meeting on occupational cancer among
women sponsoredby the NCI was published in three volumes of the
Journal of Occupational Medicine. The risk of non-Hodgkin'slymphoma
was inversely associated with intake of food high in vitamins C and A,
particularly among men. Tobacco wasassociated with the development of
prostate, colon, and pancreatic cancer. Also completed were
methodologic effortsdesigned to improve procedures for exposure
assessment in case-control and cohort studies. Currently
underinvestigation include studies of acrylonitrile,, asbestos,
benzene, butadiene, diesel exhausts, formaldehyde, methylenechloride,
nitrates in drinking water, organic solvents, pesticides, and silica.
Occupational groups with complexexposures under study include farmers,
migrant and seasonal workers, industrial workers in Turkey, lawn care
workers,fire fighters, and marine inspectors.
- References:
- Category: MEASUREMENTS
- Subcategory: EXPOSURE AND RISK MODELS, EXPOSURE DETERMINATIONS/FOLLOWUP
- Keywords for Experimental System/Species: HUMAN
- Keywords for Experimental Endpoints: EXPOSURE MONITORING, CARCINOGENESIS
- Chemical Agents: BENZENE, ACRYLONITRILE, ASBESTOS, BUTADIENE, DIESEL, FORMALDEHYDE,
METHYLENE CHLORIDE, NITRATES, PESTICIDES, SILICA
- Performing Institution: NCI INTRAMURAL PROGRAM
- Contact: ELAINE C. LEE; BUILDING 31; 11A21, NATIONAL CANCER INSTITUTE,
NIH,BETHESDA, MD 20892-2590; 301- 496-5515; LEEE@OD.NCI.NIH.GOV
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