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54349-04 Estrogenic Plant Compounds and Etiology of Breast Cancer
EDRI Federal Project Inventory:
54349-04 Estrogenic Plant Compounds and Etiology of Breast Cancer
Sponsor Organization: NIH/NCI
Project Title: 54349-04 ESTROGENIC PLANT COMPOUNDS AND ETIOLOGY OF BREAST CANCER
Project Focus: HUMAN HEALTH EFFECTS
Description: The objective of this study is to determine the response of endogenous
sex hormones to varying doses of soy derivedisoflavonoids in pre- and
postmenopausal women. Isoflavonoids have been associated with a number
of factors whichcould result in a decreased incidence and/or
progression of breast cancer. One of these factors which has been
underinvestigation in our laboratory is the interaction of these
phytoestrogens with the circulating levels of endogenousestrogen, sex
hormone binding globulin and gonadotrophins. In the first two years of
the current grant cycle it has beenobserved that feeding soy at a
single dose alters plasma and urinary estrogen and gonadotrophin
levels. More than a 3069ecline in urinary estrogen excretion and a 20
decline in plasma estrogen level were noted upon feeding a soy drink.
In this renewal application it is proposed to study the response of
female sex hormone parameters to varying levels oforally administered
isoflavonoids. These data will provide information that is necessary
to evaluate the minimal dose oforally administered isoflavonoids
required to achieve a significant and/or maximal effect on estrogen
levels in plasmaand urine. The amount of isoflavonoids excreted in the
urine and the concentration plasma will also be studied
todetermine their response to the dose of isoflavanoids ingested
orally. The relationship between urinary and plasmaisoflavonoid
concentration over a forty fold range of orally administered
isoflavonoids will be evaluated to determine ifurinary values can be
used as a reliable indicator of plasma levels.
References:
Category: MODELS
Subcategory: BASIC RESEARCH
Keywords for Experimental System/Species: LABORATORY STUDY
Keywords for Experimental Endpoints: FEMALE, HORMONAL MEASURES, CARCINOGENESIS
Chemical Agents: PHYTOESTROGENS, ISOFLAVANOIDS
Performing Institution: TUFTS UNIVERSITY BOSTON
Contact: ELAINE C. LEE; BUILDING 31; 11A21; NATIONAL CANCER INSTITUTE,
NIH,BETHESDA, MD 20892-2590; 301-496-5515; LEEE@OD.NCI.NIH.GOV
