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EDRI Federal Project Inventory:
59706-02 Pancreatic Cancer Case Control Study in San Francisco
- Sponsor Organization: NIH/NCI
- Project Title: 59706-02 PANCREATIC CANCER CASE CONTROL STUDY IN SAN FRANCISCO
- Project Focus: HUMAN HEALTH EFFECTS
- Description: The investigator propose a population-based, case-control study in men
and women to examine hypotheses linkingadenocarcinoma of the exocrine
pancreas and detailed occupational history and chemical exposures (in
particularchlorinated hydrocarbons and aromatic amines), diet,
cigarette smoking, allergies, and other factors. A molecular
geneticstudy of polymorphisms at the CYP2D6 gene locus will be
conducted to investigate the possible role of genetic riskfactors in
the metabolism of cigarette-derived chemical carcinogens in pancreatic
cancer risk. The study will include allpatients with adenocarcinoma of
the exocrine pancreas who are between the ages of 21 and 85, who speak
English orSpanish, and who live in the six-county San Francisco
Bay Area at time of diagnosis. 1000 cases and 1150 controlswill be
interviewed during the 3.5 year case- ascertainment period. Ongoing
rapid case ascertainment methods, usinghospital discharge lists and
pathology laboratories, will be employed to locate pancreatic cancer
patients in the studyarea within two weeks of diagnosis. Pathology
slides for patients will be reviewed by a senior pathologist at
theUniversity of California San Francisco (UCSF). Controls will be
identified using random digit dial and will befrequency matched to
cases by sex and 5-year age group. Two controls for each black and
Hispanic patient will beobtained to achieve adequate statistical power
and one control will be obtained for each of the other patients.
Controlsover age 65 years will be randomly selected from the rolls of
the Health Care Financing Administration in addition tothose chosen
from the general population. Structured personal interviews will be
conducted by trained interviewers instudy subjects' homes or at a
place convenient to the subject. Interview topics will include:
detailed information onoccupations and chemical and industrial
exposures, diet, medical and allergy history, medication use, family
history orpancreatic cancer and other relevant conditions, demographic
and other factors. Blood samples for genetic investigationwill be
drawn by phlebotomists in the subjects' homes. Serum will be stored in
aliquots at -40 degrees and cell sampleswill be stored frozen with
liquid nitrogen in the Irwin Memorial Blood Bank. Whole blood
specimens also will bestored for future genetic and biomarker studies.
Analyses will be conducted using univariate and multivariate
statisticswith careful attention paid to potential confounders.
- References:
- Category: MEASUREMENTS
- Subcategory: EXPOSURE AND RISK MODELS
- Keywords for Experimental System/Species: HUMAN, FIELD STUDY
- Keywords for Experimental Endpoints: RISK FACTORS, EPIDEMIOLOGY , CARCINOGENESIS, CYTOCHROME P450
- Chemical Agents: CHLORINATED HYDROCARBONS, AROMATIC AMINES
- Performing Institution: UNIVERSITY OF CALIFORNIA SAN FRANCISCO
- Contact: CONTRACT PERSON: ELAINE C. LEE; BUILDING 31; 11A21; NATIONAL CANCER
INSTITUTE, NIH,BETHESDA, MD 20892-2590; 301-496-5515;
LEEE@OD.NCI.NIH.GOV
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