EDRI Federal Project Inventory:
Multi-disciplinary Collaborative: Behavioral and Biological Effects of Chronic Social Stress
- Sponsor Organization: NATIONAL SCIENCE FOUNDATION
- Project Title: MULTIDISCIPLINARY COLLABORATIVE: BEHAVIORAL AND BIOLOGICAL EFFECTS OF
CHRONIC SOCIALSTRESS
- Project Focus: HUMAN HEALTH EFFECTS
- Description: Social stress is a common and enduring feature of life with important
behavioral andphysiological effects. A multidisciplinary research
collaboration between theLaboratory of Behavioral Neurobiology at the
University of Hawaii and the Laboratoryof Neuroendocrinology at
Rockefeller University is aimed at description and analysis ofthese
effects. Previous work indicates that single, two-week stress periods
can produceincreased defensive behavior and decreased social and
reproductive behavior; higherlevels of stress hormones and impairment
of mechanisms that normally limit stresshormone action; and widespread
changes in brain neurochemical systems. Althoughthese changes are
beginning to provide insights into the dynamics of the
physiologicaland behavioral response to chronic social stress,
completed studies have measuredonly a single time point in the
process. The proposed program will investigate thedevelopment of
stress-related behavioral and physiological changes over time, and
willdetermine the persistence of stress effects following single or
multiple periods ofchronic social stress. In addition, individual
differences will be examined asdeterminants of responsivity to social
stress. The proposed program will thus drawupon the different
approaches and expertise of these two research groups to provide
auniquely comprehensive description and analysis of the effects of
social stress in anecologically appropriate situation.
- References:
- Category: MODELS
- Subcategory: BASIC RESEARCH, MULTIDISCIPLINARY RESEARCH
- Keywords for Experimental System/Species: RODENT, MAMMAL, IN VIVO, LABORATORY STUDIES
- Keywords for Experimental Endpoints: NEUROLOGICAL, REPRODUCTIVE, HORMONE MEASURES, SEX STEROIDS, PEPTIDE
HORMONES,PHYSIOLOGY, BREEDING BEHAVIOR, STRESS RESPONSE
- Chemical Agents: Sex Steroids, Glucocorticoids
- Performing Institution: U of Hawaii Manoa & Rockefeller University
- Contact: D. C Blanchard Bruce S McEwen 2540 Maile Way
Randall R Sakai Honolulu, HI 96822-2225 66th and York Ave808
948-7837 New York, NY 10021
212 570-8000
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