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EDRI Federal Project Inventory:
Plasticity in the HPA Axis of Spawning Kokanee Salmon
- Sponsor Organization: NATIONAL SCIENCE FOUNDATION
- Project Title: PLASTICITY IN THE HPA AXIS OF SPAWNING KOKANEE SALMON
- Project Focus: ECOLOGICAL EFFECTS
- Description: Salmon fish have a remarkable reproductive cycle among vertebrate
animalsbecause in many species the adults die after spawning. It is
now known that this deathis not simply a result of the exhaustively
long migration also common to many species. Hormones of the
neuroendocrine system are involved in behaviors such asreproduction
and responses to stress. This project will use salmon as a model
systemto test the novel idea whether reproductive activity in might be
acting as the equivalentof a chronic stress, leading to advanced aging
and death in salmon. Tissue cultureand immunological techniques will
be used to determine the role of hormones secretedby the pituitary
gland or the hypothalamus, and whether, compared to other animals,
anoverproduction may cause the surge of cortisol found in spawning
animals, which mayin turn be a factor leading to early death. Results
from this study will not only beimportant for understanding the
interactions of neuroendocrine hormones and thebrain, but it also will
have an impact beyond neuroscience into the areas ofreproductive
physiology and of aging.
- References:
- Category: MODELS
- Subcategory: BASIC RESEARCH
- Keywords for Experimental System/Species: FISH, IN VIVO, LABORATORY STUDY
- Keywords for Experimental Endpoints: NEUROLOGICAL, REPRODUCTIVE, HORMONE MEASURES, SEX STEROIDS, PEPTIDE
HORMONES,PHYSIOLOGY, BREEDING BEHAVIOR, STRESS RESPONSE, MOLECULAR,
GENE EXPRESSION
- Chemical Agents: Sex Steroids
- Performing Institution: University of Denver
- Contact: Robert M Dores, Denver, CO 80208 303 871-3596
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