EDRI Federal Project Inventory:
Steroid-mimicking Properties of Xenobiotics: Mechanisms of Action and Their Rolein Amphibian Declines
- Sponsor Organization: NATIONAL SCIENCE FOUNDATION
- Project Title: STEROID-MIMICKING PROPERTIES OF XENOBIOTICS: MECHANISMS OF ACTION AND
THEIR ROLEIN AMPHIBIAN DECLINES
- Project Focus: ECOLOGICAL EFFECTS
- Description: The ultimate goal of this study is to assess and define the potential
role of pollutantsand pesticides such as DDT on the rapid
disappearance of amphibians worldwide,particularly frogs. Many of
these pollutants act on the frogs as the animal's ownsubstances do.
Consequently, a deeper understanding of the physiologic moleculesand
mechanisms may ultimately shed light on not only basic survival
mechanisms butalso disruptive mechanisms which are at the core of the
decline of these species. Another significant thrust of this project
is to involve students, both undergraduate andgraduate, in various
stages of the project, thereby allowing them not only to develop
asfuture scientists but also to acquire an awareness of this
significant disruption ofbiological life.
- References:
- Category: MODELS
- Subcategory: BASIC RESEARCH
- Keywords for Experimental System/Species: IN VIVO, AMPHIBIAN, LABORATORY/FIELD STUDY
- Keywords for Experimental Endpoints: NEUROLOGICAL, REPRODUCTIVE, HORMONE RECEPTORS, SEX STEROIDS, PUBERTY,
GROWTH,PEPTIDE HORMONES, MOLECULAR,
- Chemical Agents: DDT, Sex Steroids
- Performing Institution: University of California Berkeley
- Contact: Tyrone B Hayes, Berkeley, CA 94720 415 642-6000
tyrone@garnet.berkeley.edu
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