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EDRI Federal Project Inventory:
Ecdysteroid and Retinoid Receptors in Crustacea: Expression in Regenerating Limbs
- Sponsor Organization: NATIONAL SCIENCE FOUNDATION
- Project Title: ECDYSTEROID AND RETINOID RECEPTORS IN CRUSTACEA: EXPRESSION IN
REGENERATINGLIMBS
- Project Focus: ECOLOGICAL EFFECTS
- Description: Crustaceans regenerate new walking legs when old ones are lost or
injured.Ecdysteroids (the invertebrate steroid hormones) which control
growth in virtually allarthropods also influence the special kind of
growth involved in regeneration. Theresearch proposed here will
investigate the role of these steroids in leg regeneration inthe crab,
Uca pugilator. Since regeneration in crabs involves both
cellulardifferentiation and anabolic activities, this research will
yield new insights into themolecular controls of these two very
different events. Using our recently isolated DNAprobe for the
ecdysteroid receptor, Dr. Hopkins will look at the patterns of
receptorexpression during regeneration and the structural/functional
relationships betweensteroid hormones, other growth-affecting
compounds (such as the retinoids), and theirreceptors. Because
steroid receptors of invertebrates are so similar to those of
highervertebrates, the data generated by this research should provide
a better understandingof how steroids, in general, control and
coordinate the complicated phenomena ofgrowth.
- References:
- Category: MODELS
- Subcategory: BASIC RESEARCH
- Keywords for Experimental System/Species: CRUSTEAN, INVERTEBRATES, IN VIVO, IN VITRO, LABORATORY STUDY
- Keywords for Experimental Endpoints: NEUROLOGICAL, REPRODUCTIVE, HORMONE MEASURES, SEX STEROIDS, PEPTIDE
HORMONES,PHYSIOLOGY, BREEDING BEHAVIOR, GROWTH, MOLECULAR, GENE
EXPRESSION
- Chemical Agents: Sex Steroids
- Performing Institution: University of Oklahoma
- Contact: Penny M Hopkins & David S Durica, 660 Parrington Oval, Norman, OK
73069-8813 405 325-0311
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