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EDRI Federal Project Inventory:
The Cloning of a Putative Brain Membrane Estrogen Receptor (MER)
- Sponsor Organization: NATIONAL SCIENCE FOUNDATION
- Project Title: THE CLONING OF A PUTATIVE BRAIN MEMBRANE ESTROGEN RECEPTOR (MER)
- Project Focus: HUMAN HEALTH EFFECTS
- Description: Steroid hormones derived from the gonads or the adrenals, have long
been known tohave profound effects on cellular and organismal
function. The classical mechanism bywhich these hormones affect
cellular function is by interacting with intracellularreceptors,
which upon binding translocate to the nucleus of the cell and alter
geneexpression. However, recent physiological experiments have
revealed that steroidhormones also bind to membrane-rich cellular
fractions and exert rapid effects onneuronal cells. Dr. Ramirez is
isolating and characterizing these binding sites able to elicit
rapidchanges in cellular function. In these investigations, Dr.
Ramirez is using a brainlibrary to isolate a cDNA clone for this novel
receptor and to characterize the encodedprotein. If successful, the
research supported by this SGER award will greatly changeour
understanding of steroid hormone action in the brain and open an
entire new fieldof scientific investigation in the neurosciences.
- References:
- Category: MODELS
- Subcategory: BASIC RESEARCH
- Keywords for Experimental System/Species: RODENT, MAMMAL, IN VITRO, IN VIVO, LABORATORY STUDIES
- Keywords for Experimental Endpoints: NEUROLOGICAL, REPRODUCTIVE, MOLECULAR, GENE EXPRESSION, HORMONE
RECEPTORS SEXSTEROIDS, PHYSIOLOGY, BREEDING BEHAVIOR
- Chemical Agents: Sex Steroids
- Performing Institution: University of Illinois Urbana- Champaign
- Contact: Victor D Ramirez, 801 South Wright Street, Champaign, IL 61820
217 333-2186, vdramire@ux4.cso.uiuc.edu
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