EDRI Federal Project Inventory:
Endocrine Regulation of the Ecdysteroid Cascade During Insect Metamorphosis
- Sponsor Organization: NATIONAL SCIENCE FOUNDATION
- Project Title: ENDOCRINE REGULATION OF THE ECDYSTEROID CASCADE DURING INSECT
METAMORPHOSIS
- Project Focus: ECOLOGICAL EFFECTS
- Description: Ecdysteroids cause insect molting and metamorphosis, and juvenile
hormone ispresent during larval life to allow growth and molting and
to prevent metamorphosis.Interference with the action of these
hormones is one way to control insect pests. Dr.Riddiford has found
that there is a dynamic and complex pattern of changingecdysteroid
receptor isoforms and its partner USP during a molt and at
metamorphosisin the epidermis of the tobacco hornworm, Manduca sexta.
She now plans to studyboth the hormonal and the spatiotemporal
regulation of these receptors and the initialtranscription factors
that they induce at the cellular level using
primarilyimmunocytochemical and in situ hybridization analysis of
tissue exposed to thesehormones both in vivo and in vitro. These
studies will provide deeper insight into howthe ecdysteroids initiate
and coordinate the cellular responses that lead to theformation of a
new cuticle during a molt and during the switch in cell fate that
isessential for metamorphosis. By studying the influence of juvenile
hormone on thesecellular dynamics, she will shed new light on its mode
of action in the prevention of theswitch of cell fates.
- References:
- Category: MODELS
- Subcategory: BASIC RESEARCH
- Keywords for Experimental System/Species: INVERTEBRATES, IN VIVO, IN VITRO, LABORATORY STUDIES
- Keywords for Experimental Endpoints: NEUROLOGICAL, REPRODUCTIVE, HORMONE MEASURES, SEX STEROIDS, PEPTIDE
HORMONES,PHYSIOLOGY, BREEDING BEHAVIOR, MOLECULAR, GENE EXPRESSION,
HORMONE RECEPTORS
- Chemical Agents: Sex Steroids
- Performing Institution: University of Washington
- Contact: Lynn M Riddiford, Seattle, WA 98195 206 543-2100
lmr@u.washington.edu
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