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EDRI Federal Project Inventory:
Testosterone-Serotonin Interactions in Aggression
- Sponsor Organization: NATIONAL SCIENCE FOUNDATION
- Project Title: TESTOSTERONE-SEROTONIN INTERACTIONS IN AGGRESSION
- Project Focus: HUMAN HEALTH EFFECTS
- Description: The expression of aggressive behavior by males is regulated through
the activity ofhormonal and neurochemical systems within the brain.
The key messenger molecule inthe brain involved in aggressive
behaviors appears to be the indolamine, serotonin,which decreases
aggression. In addition, a key hormonal component involved
inaggression is the androgenic hormone, testosterone, which
facilitates behavioralexpression. Dr. Simon will define whether and
how testosterone modulates the abilityof serotonin to decrease
aggression. To determine the relationship between theseimportant
messenger molecules the ability of testosterone to modulate the
behavioraleffects of serotonin, the site of testosterone action
within the central nervous system,and the ability of this potent
androgen to alter serotonin binding characteristics will
beinvestigated. These investigations will produce exciting new
information about theneurochemical andneuroendocrinological
interactions involved in aggressive behaviors in animals andhumans.
- References:
- Category: MODELS
- Subcategory: BASIC RESEARCH
- Keywords for Experimental System/Species: RODENT, MAMMAL, IN VIVO, LABORATORY STUDIES
- Keywords for Experimental Endpoints: NEUROLOGICAL, REPRODUCTIVE, HORMONE MEASURES, SEX STEROIDS, PEPTIDE
HORMONES,PHYSIOLOGY, BREEDING BEHAVIOR
- Chemical Agents: Sex Steroids, Peptide Hormones
- Performing Institution: Lehigh University
- Contact: Neal G Simon, Alumni Building 27, Bethlehem, PA 18015-3005 610
861-3000
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