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EDRI Federal Project Inventory:
Mapping and Characterization of Genes Controlling Ovarian Function in Mice
- Sponsor Organization: NATIONAL SCIENCE FOUNDATION
- Project Title: MAPPING AND CHARACTERIZATION OF GENES CONTROLLING OVARIAN FUNCTION IN
MICE
- Project Focus: HUMAN HEALTH EFFECTS
- Description: Recent studies have discovered major genetic differences in the
control ofreproduction, especially in ovarian responsiveness to
hormones. Dr. Spearow hasfound that the hormone-induced ovulation
rate (HIOR) of one strain of mice is six timeshigher than in a second
genetic strain of mice. Furthermore, the enzyme aromatase,responsible
for generating the hormone, is 16 to 21 times higher in the second
strain ofmice. This enzyme converts androgens into estrogens. He has
found that geneticdifferences in these reproductive traits segregate
in crosses as though they arecontrolled by the action of a small
number of loci with major effects. The proposedstudies will utilize
mouse genetic models to confirm and characterize the
physiologicalmechanisms by which genes on mouse chromosome 2 control
major differences inovarian response to gonadotropins. These studies
will also characterize and clone thegenes which control major genetic
differences in ovarian function. Identifying geneticmarkers for
divergent hormone responsive genotypes, and determining
thephysiological mechanisms through which these genes control
differences in ovarianfunction could aid in improving and controlling
reproduction in a wide range ofmammalian species.
- References:
- Category: MODELS
- Subcategory: BASIC RESEARCH
- Keywords for Experimental System/Species: RODENT, MAMMAL, IN VIVO, IN VITRO, LABORATORY STUDIES
- Keywords for Experimental Endpoints: REPRODUCTIVE, HORMONE MEASURES, SEX STEROIDS, PEPTIDE HORMONES,
HORMONERECEPTORS, PHYSIOLOGY, BREEDING BEHAVIOR, PUBERTY, MOLECULAR,
GENE EXPRESSION
- Chemical Agents: Sex Steroids, Peptide Hormones
- Performing Institution: University of California Davis
- Contact: Jimmy L Spearow, 410 Mrak Hall, Davis, CA 95616-8671 916/752-2075
jlspearow@ucdavis.edu
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