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Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC)

April 26-28, 2005 Meeting

Agenda

PDF File [4pp., 17KB, About PDF] HTML File [18KB]

Federal Register Notices Announcing Meeting | Copy for Public Comment

Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC); Notice of Public Meeting [PDF file, 3pp., 58KB, About PDF]

Background Documents and Corresponding Presentation(s)

Amphibian Metamorphosis Assay

Amphibian Metamorphosis Assay Questions from EPA for the EDMVAC

OECD Detailed Review Paper on Amphibian Metamorphosis Assay for the Detection of Thyroid Active Substances [PDF file, 106pp., 521KB, About PDF]

OECD Draft Report of the Validation of the Amphibian Metamorphosis Assay for the Detection of Thyroid Active Substances: Phase 1 - Optimisation of the Test Protocol [PDF file, 83pp., 2.8MB, About PDF]

U.S. Pathology Report for PTU [PDF file, 18pp., 522KB, About PDF]

Japan Histology Results for 14-day PTU Assay [PDF file, 3pp., 57KB, About PDF]

Germany Thyroid Histology Report [PDF file, 17pp., 972KB, About PDF]

Presentation: "Amphibian Metamorphosis Assay for Thyroid Disruption: Status Report" by Sigmund J Degitz [PDF file, 58pp., 541KB, About PDF]

The Story of the Amphibian Metamorphosis Assay in EPA's Endocrine Disruptor Screening Program [PDF file, 2pp., 12KB, About PDF] [HTML File]

Fish Screen Assay

Fish Screen Assay Questions from EPA for the EDMVAC

U.S. EPA/ORD Report: Short-term Test Method for Assessing the Reproductive Toxicity of Endocrine-Disrupting Chemicals Using the Fathead Minnow (Pimephales promelas) [PDF file, 170pp., 7.3MB, About PDF] or HTML version

OECD Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances [PDF file, 170pp., 909KB, About PDF]

Draft Final Report on Multi-Chemical Evaluation of the Short-Term Reproduction Assay with the Fathead Minnow [PDF file, 165pp., 925KB, About PDF]

OECD Revised Draft Report Phase 1B of the Validation of the 21-day Fish Assay for the Detection of Endocrine Active Substances [PDF file, 92pp., 754KB, About PDF]

Best Practices Guideline: Toxicologic Histopathology [PDF file, 6pp., 63KB, About PDF]

Presentation: "Fish Screen Histopathology" by Dr. Jeffrey Wolf [PDF file, 136pp., 5.7MB, About PDF]

Ankley/Johnson Review Paper: Small Fish Models for Identifying and Assessing the Effects of Endocrine-disrupting Chemicals [PDF file, 15pp., 228KB, About PDF]

Presentation: "Technical Underpinnings and Initial Validation of a Fish Assay for Detecting EDCs" by Dr. Gerald Ankley [PDF file, 93pp., 3.7MB, About PDF]

The Story of the Fish Screening Assay in EPA's Endocrine Disruptor Screening Program [PDF file, 4pp., 17KB, About PDF] [HTML File]

Steroidogenesis Assay

Steroidogenesis Assay Questions from EPA for the EDMVAC

Sliced Testis Assay Prevalidation: Multi-Chemical Study [PDF file, 56pp., 237KB, About PDF]

Sliced Testis Assay Prevalidation: Multi-Laboratory Baseline/Positive Control Study [PDF file, 98pp., 1.6MB, About PDF]

Presentation: "Steroidogenesis: The Sliced Testis Protocol" by Dr. Jerome Goldman [PDF file, 42pp., 228KB, About PDF]

The Story of the Steroidogenesis Assay in EPA's Endocrine Disruptor Screening Program [PDF file, 3pp., 14KB, About PDF] [HTML File]

Uterotrophic Assay

Uterotrophic Assay Questions from EPA for the EDMVAC

Detailed Background Review of the Uterotrophic Bioassay [PDF file, 217pp., 1.6MB, About PDF]

OECD Report of the Initial Work Towards the Validation of the Rodent Uterotrophic Bioassay: Phase 1 [PDF file, 140pp., 622KB, About PDF]

OECD Draft Report of the Validation of the Rodent Uterotrophic Bioassay: Phase 2. Testing of Potent and Weak Oestrogen Agonists by Multiple Laboratories [PDF file, 138pp., 939KB, About PDF]

Presentation: The Validation of of the Uterotrophic Bioassay by Dr. William Owens [PDF file, 91pp., 699KB, About PDF]

The Story of the Uterotrophic Assay in EPA's Endocrine Disruptor Screening Program [PDF file, 8pp., 27KB, About PDF] [HTML File]

EDMVAC Background Documents

Background Presentation: "Overview of the Federal Advisory Committee Act (FACA)" [PDF file, 12pp., 146KB, About PDF]

DRAFT EDMVAC Operating Procedures [PDF file, 8pp., 155KB, About PDF]

Background Presentation: "DRAFT EDMVAC Workplan" by Jane Smith [PDF file, 22pp., 94KB, About PDF]

Background Presentation: "Overview of the Endocrine Disruptor Screening Program" [PDF file, 18pp., 185KB, About PDF]

Background Presentation: "Who's Who in the Validation of the Assays for EDSP" by Gary Timm [PDF file, 42pp., 101KB, About PDF]

Public Comments

Comments by Dr. Lisa Ortego of American Chemistry Council (ACC) [PDF file, 4pp., 41KB, About PDF]

Comments by Dr. Vincent Kramer on behalf of ACC and CLA (Crop Life of America) [PDF file, 3pp., 69KB, About PDF]

Comments by Dr. Richard Becker of ACC [PDF file, 9pp., 1.6MB, About PDF]

Comments by Dr. James Stevens of the EDMVAC [PDF file, 3pp., 126KB, About PDF]

EDMVAC Recommendations

EDMVAC Consensus Recommendation on the Continued Development of the Sliced Testis Steroidogenesis Assay [PDF file, 3pp., 166KB, About PDF]

EPA agrees with the EDMVAC recommendation [PDF file, 1pp., 44KB, About PDF]

Meeting Summary

Meeting Summary [PDF file, 35pp., 184KB, About PDF]


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