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Endocrine Disruptor Methods Validation Subcommittee (EDMVS)

Eighth Plenary Meeting - August 18-20, 2003

Agenda

PDF File [3pp., 150KB, About PDF] HTML File [17KB]

Federal Register Notices Announcing Meeting | Copy for Public Comment

Endocrine Disruptor Methods Validation Subcommittee under the National Advisory Council for Environmental Policy and Technology; Notice of Public Meeting [PDF file, 4pp., 50KB, About PDF]

Background Documents and Corresponding Presentation(s)

Fish Screening Assays

Comparative Evaluation of Vitellogenin Methods in Fathead Minnow [PDF file, 51pp., 519KB, About PDF]

Presentation: Results of the Comparative Evaluation of the Fathead Minnow [PPT file, 60pp., 2.4MB]

Draft Final Report on Survey of Vitellogenin Methods in Zebrafish and Medaka [PDF file, 34pp., 954KB, About PDF]

Presentation: Results of the Survey of Vitellogenin Methods in Zebrafish and Medaka [PPT file, 25pp., 4.5MB]

Draft Final Report on Comparative Evaluation of the Fathead Minnow:

Section 1 and 2: Introduction and methods [PDF file, 49pp., 1.72MB, About PDF]

Section 3: Methoxychlor [PDF file, 69pp., 472KB, About PDF]

Section 4: Trenbolone [PDF file, 62pp., 1MB, About PDF]

Section 5: Flutamide [PDF file, 64pp., 900KB, About PDF]

Section 6: Fadrozole [PDF file, 67pp., 780KB, About PDF]

Section 7-8: Discussion and References [PDF file, 13pp., 250KB, About PDF]

Presentation: Results of the Survey of Vitellogenin Methods in Fathead Minnow [PPT file, 25pp., 4.5MB]

Presentation: OECD Phase 1A - Feasibility to Demonstrate the Fish Screen (Nonspawning) Method [PDF file, 31pp., 112KB] Note: In order to properly view this file, you must install the latest version of Adobe Acrobat's Asian Font Pack for JapaneseExit Disclaimer.

Questions for the EDMVS regarding the Fish Screening Assays [PDF file, 1pp., 60KB, About PDF]

Pubertal Assays

The documents referenced below are accessible from the CRC website,Exit Disclaimerfor a fee. The items may also be available from a local library.

Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Function in the Male Rat. A Focus on the EDSTAC Recommendations. This item is available in Critical Reviews in Toxicology, Volume 30 #2: Pages 197-252 (2000)

Presentation: Issues Related to the Pubertal Assay [Lotus PRZ file, 3MB]

Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Function in the Female Rat. A Focus on the EDSTAC Recommendations. This item is available in Critical Reviews in Toxicology, Volume 30 #2: Pages 135 - 196 (2000)

Steroidogenesis Assay

Unaudited Final Draft Report on Optimization of the Sliced Testis [PDF file, 243pp., 6MB, About PDF]

Presentation: Optimized Protocol [PPT file, 34pp., 989KB]

Draft Study Plan for Prevalidation of the Sliced Testis [PDF file, 78pp., 470KB, About PDF]

Presentation: Prevalidation Study Plan [PPT file, 30pp., 134KB]

Avian Assay

Revised Draft Detailed Review Paper [PDF file, 162pp., 659KB, About PDF]

Presentation: Detailed Review Paper [PPT file, 25pp., 317KB]

Questions for the EDMVS regarding the Avian Assay [PDF file, 1pp., 56KB, About PDF]

Other Topics

White Paper on Species/Strain/Stock in Endocrine Disruptor Assays [PDF file, 97pp., 564KB, About PDF]

Presentation: Strain/Species White Paper [PPT file, 25pp., 2.7MB]

Questions To EDMVS on Strain/Species for Mammalian Assays [PDF file, 2pp., 34KB, About PDF]

Update on Chemicals Used in EDMVS

Disclaimer and Questions for the EDMVS [PDF file, 2pp., 56KB, About PDF]

ER Modality [PDF file, 1pp., 39KB, About PDF]

AR Modality [PDF file, 1pp., 39KB, About PDF]

Other Modalities [PDF file, 2pp., 44KB, About PDF]

Public Comments

 

Meeting Summary

Meeting Summary [PDF file, 40pp., 596KB, About PDF]


PLEASE NOTE:

Some of the documents presented may not be accessible using alternative access devices. If you need access to these documents please contact William Wooge at 202-564-8476. We will post accessible documents as soon as possible.

Documents presented on this page may be in Microsoft PowerPoint (PPT), Microsoft Excel (XLS), or Lotus Freelance Format (PRZ). To view or print them you will need to have their associated programs installed on your computer. The programs can be downloaded and used with no charge from the following links.


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