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Endocrine Disruptor Methods Validation Subcommittee (EDMVS)
After the Endocrine Disruptor Screening
and Testing Advisory Committee (EDSTAC) completed its work and disbanded
in 1998, EPA organized a Standardization
and Validation Task Force (SVTF)
consisting of representation from a broad range of sectors, including
federal agencies, agrichemical companies, commodity chemical companies,
and environmental and public health organizations to coordinate and conduct
the scientific and technical work necessary to validate the screens and
tests recommended by the EDSTAC. In 2001, SVTF was replaced by the EDMVS whose meetings are conducted
according to the Federal Advisory Committee Acts (FACA). The mission of
EDMVS is to provide technical input to EPA for the assays recommended
by EDSTAC. EDMVS critically examines each step of the validation process
for the assays and was established as a subcommittee under the auspices
of EPA's National
Advisory Council for Environmental Policy and Technology (NACEPT).
NACEPT and its EDMVS work to ensure that scientifically-sound assays are
developed for animal- and non-animal-based endocrine disruptor screens
and tests during the validation process. NACEPT and EDMVS also ensure
that people and organizations have the opportunity to comment and express
their concerns and issues associated with the assays and processes.
EDMVS members have expertise in mammalian, ecological, and in vitro endocrine disruptor screening and testing methods; toxicity test methods standardization and validation; and/or chemical and pesticide regulatory processes. EDMVS members represent the agrichemical and commodity chemical industries, environmental organizations, public health organizations, academia, animal welfare organizations, federal agencies, and state governments. As a charter member and co-chair of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), EPA (and EDMVS) is following the interagency validation framework in the development and refinement of assays to reduce animal use, refine procedures involving animals to make them less stressful, and replace animals where scientifically appropriate.
EDMVS holds up to six meetings per year in accordance with the Federal Advisory Committee Act (FACA)/NACEPT rules. At these meetings EDMVS members review pre-validation and validation reports and data for all the assays/tests, review protocols, review study plans, and provide recommendations on animal welfare issues.
- EDMVS's Mission [PDF, 2pp., 8KB, About PDF]
- EDMVS Subcommittee Members
- Report to the U.S. House of Representatives Committee on Appropriations on the Status of the Endocrine Disruptor Methods Validation Subcommittee [PDF, 6pp., 19KB, About PDF] and Appendix [PDF, 9pp., 24KB, About PDF]
- EDMVS Meetings and Meeting Support Materials
- Pre-EDMVS Assay Development Activities
You will need the free Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more. If you need help accessing these PDF documents, please contact William Wooge at 202-564-8476 or wooge.william@epa.gov for assistance.