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Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC)
Plenary Meeting - November 30 - December 2, 2005

Draft Agenda

Holiday Inn Brownstone Hotel & Conference Center Exit Disclaimer
1707 Hillsborough Street
Raleigh, NC 27605; (919) 828-0811

Meeting Objectives:

EPA provides updates on:

  1. the status of the Male and Female Pubertal Rat Assay;
  2. the Avian Species Comparison Study; and
  3. the optimization of Steroidogenesis using the H295R cell line.

EDMVAC provide advice on:

  1. EDSP's applied approach to validation;
  2. the Avian Dosing Study;
  3. the next steps for the Avian 2-Generation Tier II Assay; and
  4. the outcomes of the OECD Uterotrophic Peer Review Report.

Wednesday, November 30, 2005

8:30 - 8:40am Welcome and Opening Comments

Dr. Gerald LeBlanc, EDMVAC Chair
Dr. Tom Osimitz, EDMVAC Co-Chair

8:40 - 9:00 Introductions, Meeting Purpose, Agenda Review, and EDMVAC Workplan

Dr. Juliana Birkhoff , Facilitator, RESOLVE
Ms. Jane Smith, EPA Endocrine Disruptors Screening Program

9:00 - 9:30 Update on the Status of the Male and Female Pubertal Assay

Presenter: Mr. Jim Kariya, EPA Endocrine Disruptors Screening Program

9:30 - 10:15 Presentation of the Avian Species Comparison Study - A Protocol Development Study for the Avian 2-Generation Tier II Assay

Presenter: Dr. Mary Ann Ottinger, University of Maryland

10:15 - 10:35 BREAK

10:35 - 11:50 Discussion of the Avian Species Comparison Study

Facilitated discussion among EDMVAC members

11:50 - 1:30 LUNCH

1:30 - 2:45pm Update on Optimization of the Protocol for the Steroidogenesis Assay Using the H295R Cell Line

Presenter : Dr. Markus Hecker, Michigan State University

2:45 - 3:00 BREAK

3:00 - 4:00 Discussion Continued on Steroidogenesis Assay Using the H295R Cell Line

Facilitated discussion among EDMVAC members

4:00 - 4:45 Public Comment

4:45 - 5:00 Wrap-Up and Closing Remarks

Dr. Gerald LeBlanc, EDMVAC Chair
Dr. Tom Osimitz, EDMVAC Co-Chair

5:00pm Adjourn to Dinner

Thursday, December 1, 2005

8:15 - 8:30am Review of Day 1 and Agenda for Day 2

Dr. Juliana Birkhoff, Facilitator, RESOLVE

8:30 - 10:30 EDSP's Applied Approach to Assay Validation

Presenter(s): Mr. Gary Timm, Dr. Les Touart, and Dr. Linda Phillips, EPA Endocrine Disruptors Screening Program

10:30 - 10:45 BREAK

10:45 - 12:30pm EDMVAC Discussion of Assay Validation

Facilitated discussion among EDMVAC members

12:30 - 1:30 LUNCH

1:30 - 3:00pm Presentation and Introduction to the Avian Dosing Study - A Protocol Development Study for the Avian 2-Generation Tier II Assay

Presenters: Dr. Les Touart and Dr. Christiana Grim, EPA Endocrine Disruptor Screening Program

3:00 - 3:15 BREAK

3:15 - 5:15 Discussion of the Avian Dosing Study and the Next Steps for the Avian 2-Generation Tier II Assay

Facilitated discussion among EDMVAC members

5:15 - 5:25 BREAK

5:25 - 6:00 Public Comment

6:00 - 6:30 Wrap-Up and Closing Remarks

Dr. Gerald LeBlanc, EDMVAC Chair
Dr. Tom Osimitz, EDMVAC Co-Chair

6:30pm Adjourn to Dinner

Friday, December 2, 2005

8:30 - 8:45am Review of Day 2 and Agenda for Day 3

8:45 - 9:45 Presentation and Discussion of the Outcomes of the OECD Uterotrophic Peer Review Report

Presenter: Dr. J. William Owens, The Procter and Gamble Company and Mr. Gary Timm, EPA Endocrine Disruptors Screening Program

9:45 - 10:00 BREAK

10:00 - 11:00 Discussion Continued on the Outcomes of the OECD Uterotrophic Peer Review Report

Facilitated discussion among EDMVAC members

11:00 - 11:30 Wrap-Up and Closing Remarks

Dr. Gerald LeBlanc, EDMVAC Chair
Dr. Tom Osimitz, EDMVAC Co- Chair

11:30am Adjourn


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