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National Advisory Council for Environmental Policy and Technology (NACEPT)
Endocrine Disruptor Methods Validation Subcommittee (EDMVS)
Third Plenary Meeting - March 25-27, 2002

DRAFT Agenda

RESOLVE
1255 23rd Street, N.W., Suite 275
Washington, DC 20037
(202) 944-2300

Members of the public may join this conference call in person at the conference room in the RESOLVE offices at 1255 23rd St. NW, Suite 275, Washington, DC. To register to participate by phone, please contact Jane Smith, designated federal official for the EDMVS, at smith.jane-scott@epa.gov or (202) 564-8476. Also note that members of the public who would like to make comments during the conference call need to contact Ms. Smith prior to the

Meeting Objectives

Monday, March 25, 2002

1:00 - 1:10 Welcome and Opening Comments

Dr. Vanessa Vu, EDMVS Chair and Director, Office of Science Coordination and Policy (OSCP), EPA
Dr. William Benson, EDMVS Vice-Chair, Office of Research and Development (ORD), EPA

1:10 - 1:30 Introduction, Agenda Review, and Review of Previous Meeting Summary

Paul De Morgan, Facilitator, RESOLVE

1:30 - 2:00 Review of EDMVS Work Plan

Jane Smith, EDMVS Designated Federal Official, OSCP, EPA

2:00 - 3:00 Practical Aspects of the Implementation of the Validation Process by the EDSP

Gary Timm, OSCP, EPA

3:00 - 3:15 Break

3:15 - 3:45 Chemicals Used in Prevalidation of EDSP-related Assays

Jim Kariya, OSCP, EPA

3:45 -4:15 Overview of Ecotoxicological Assays

Dr. Les Touart, OSCP, EPA

4:15 - 5:00 Special Study: Tier 2 Avian Dosing Study

Dr. Les Touart, OSCP, EPA

5:00 - 5:30 Public Comment

Members of the public will be given an opportunity to comment on any aspect of the EDMVS work. The amount of time given to each individual will depend on the number of people wishing to provide comment.

5:30 - 5:45 Setting the Stage for Day Two

5:45 Adjourn for the day

Tuesday, March 26, 2002

9:00 - 9:15 Settling In

9:15 - 10:45 Short-Term Fish Reproduction Assay and Discussion of the Fish Screening Assays Detailed Review Paper

Dr. Les Touart, OSCP, EPA
Dr. Gary Ankley, Midcontinent Ecology Division, National Health and Environmental Effects Research Laboratory (NHEERL), ORD, EPA

10:45 - 11:00 Break

11:00 - 11:45 Special Study: Comparative Evaluation of Fathead Minnow Assays

Dr. Les Touart, OSCP, EPA

11:45 - 1:00 Lunch

1:00 - 1:45 Special Study: Comparative Evaluation of Vitellogenin Methods

Dr. Les Touart, OSCP, EPA

1:45 - 2:30 Discussion of Core Chemicals Used in Prevalidation of EDSPrelated Assays

Jim Kariya, OSCP, EPA

2:30 - 3:00 Sources of Data Used in Assessing Human Health Effects

Dr. Vanessa Vu, Director, OSCP, EPA

3:00 - 3:15 Break

3:15 - 3:45 EPA's Approach to Addressing Low Dose Issues

Dr. Vanessa Vu, Director, OSCP, EPA

3:45 - 4:15 Public Comment

Members of the public will be given an opportunity to comment on any aspect of the EDMVS work. The amount of time given to each individual will depend on the number of people wishing to provide comment.

4:15 - 4:30 Setting the Stage for Day Three

4:30 Adjourn for the day

Wednesday, March 27, 2002

9:00 - 9:15 Settling In

9:15 - 10:45 Aromatase Detailed Review Paper

Dr. Susan Laws, Reproductive Toxicology Division, NHEERL, ORD, EPA

10:45 - 11:00 Break

11:00 - 12:00 In Utero Through Lactation Protocol

Gary Timm, OSCP, EPA
Dr. Earl Gray, ORD, EPA

12:00 - 12:45 Next Steps and Agenda for Fourth Meeting

12:45 Adjourn


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