Universe of Chemicals from which the June 2007 Draft List was Selected
The universe of chemicals from which the June 2007 draft list was selected included over 1,700 pesticide chemicals. This page presents an overview of the subsets of chemicals from which the draft list of 73 chemicals for initial Tier 1 screening was selected. EPA indicated in the September 27, 2005 Federal Register Notice (PDF) (17 pp, 125K, About PDF), that the universe of chemicals to be considered for initial screening would include: 1) pesticide active ingredients and 2) high production volume (HPV) chemicals that are also pesticide inerts.
The Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) defines a pesticide active ingredient as a chemical contained in pesticide products that prevents, destroys, repels, or mitigates any pest, or is a plant regulator, defoliant, desiccant, or nitrogen stabilizer. (7 U.S.C. 136a(2)(u)). The universe of pesticide active ingredients which are required to be screened for their potential to adversely affect the endocrine system corresponds to the active ingredients EPA has scheduled for review in its "registration review" program. The registration review schedule identifies all pesticide active ingredients that are used in currently registered products and indicates when they will be addressed in EPA's periodic registration review program.
- The draft registration review schedule was posted on EPA's Web site in August 2005. The draft schedule listed all registration review cases and pesticide active ingredients as of September 30, 2004.
- The draft schedule listed 666 registration review cases, comprising 1,056 active ingredients. Only those pesticide active ingredients that appear on this draft schedule were considered for generating the initial list of chemicals to undergo testing in the EDSP.
- The list is consistent with the final registration review schedule posted in October 2006. The principal difference between the draft and the final schedule is the inclusion of new active ingredients contained in newly registered pesticides as of September 30, 2005. The Agency does not expect any of the newly added active ingredients to be found in multiple exposure pathways.
- There are currently 678 registration review cases, comprising 1,077 active ingredients. These numbers will change annually as registration review schedule updates are announced.
HPV chemicals are those substances that are not pesticide active ingredients and that are produced or imported into the U.S. in amounts greater than or equal to one million pounds per year. The list of HPV chemicals is based on the non-confidential list of 2002 Toxic Substances Control Act (TSCA) Inventory Update Rule (IUR) chemicals. A total of 2,708 HPV chemicals were identified.
Pesticide inert chemicals are defined as any ingredients in pesticide product formulations other than the active ingredient. (7 U.S.C. 136a (m)). A total of 2,775 pesticide inert chemicals were identified. OPP maintains an inventory of pesticide inert chemicals that are categorized into the following four lists:
- List 1 - Inert Ingredients of Toxicological Concern. Any product containing a List 1 ingredient must include the label statement "This product contains the toxic inert ingredient (name of inert)."
- List 2 - Potentially Toxic Inert Ingredients/High Priority for Testing Inerts. The substances on this list may be structurally similar to chemicals known to be toxic; some have data suggesting a concern.
- List 3 - Inerts of Unknown Toxicity. Inert ingredients on this list have not yet been determined to be of known potential toxicological concern nor have they been determined to be of minimal concern. These substances will continue to be evaluated to determine if they merit reclassification to List 1, 2, or 4.
- List 4 - Inerts of Minimal Concern. This list is subdivided into List 4A (minimal risk inert ingredients) and List 4B (inerts which have sufficient data to substantiate that they can be used safely in pesticide products).
A total of 643 chemicals were identified that are both an HPV and pesticide inert chemical.