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Priority Setting Activities
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Priority Setting is one of three major components of the Endocrine Disruptor Screening Program (EDSP) (the other two are Tier 1 and Tier 2 assay development and validation and development of program policies and procedures to require testing). "Priority setting" in EDSP refers to identifying which chemicals will undergo Tier 1 Screening first.
Access information describing EDSP priority setting activities:
- Universe of Chemicals
- Chemical Selection for the Second List
- Chemical Selection for the Initial List
- Early Priority Setting Activities
Universe of Chemicals
Developed in response to recommendations from the Office of Inspector General, The EDSP Universe of Chemicals and General Validation Principles (17 pp, 197.94K, About PDF) document provides an overview of the general validation principles that will be used to evaluate computational toxicological methods for chemical prioritization. EPA has also presented the List of EDSP Universe of Chemicals (177 pp, 2.54M, About PDF) as a separate document which will be updated as new information becomes available. The List of the EDSP Universe of Chemicals contains approximately 10,000 chemicals as defined under FFDCA and SDWA 1996 amendments, although not all of the chemicals are expected to undergo EDSP Tier 1 screening. The agency plans to prioritize these chemicals for screening by considering physical chemical properties, exposure, and an effect-based approach using advanced computational toxicological methods. These methods and tools will be evaluated using OECD validation principles for their utilization in chemical prioritization and this topic was the focus of a January 29-31, 2013 FIFRA Science Advisory Panel meeting.
Chemical Selection for the Second List of Chemicals
Highlights
June 14, 2013 – Revised Second List of Chemicals for Tier 1 Screening. This revised second list consists of 109 identified chemicals, 41 of which are pesticide active ingredients (PAIs) and 68 are chemicals identified under the Safe Drinking Water Act (SDWA). Visit the links below to learn more about the revised second list of chemicals:
- Overview of the Revised Second List of Chemicals for Tier 1 Screening
- Revised Second List of Chemicals for Tier 1 Screening
November 17, 2010 - Draft Second List of Chemicals for Tier 1 Screening. This list included 134 chemicals and substances that have been listed as priorities within EPA’s drinking water and the pesticides programs.
Visit the links below to learn more about the second list of chemicals:
- Overview of the Second List of Chemicals for Tier 1 Screening
- Second List of Chemicals for Tier 1 Screening
Chemical Selection for the Initial List of Chemicals
- April 2009 - EPA published the Final List of Initial Pesticide Active Ingredients and Pesticide Inert Ingredients to be Screened under the Federal Food, Drug, and Cosmetic Act (PDF) (7pp, 62K, About PDF), in a Federal Register Notice.
- June 2007 – EPA implemented its approach for the priority setting process to select chemicals within the scope of EDSP. EPA generated a draft list of chemicals for initial Tier 1 Screening and published the draft list of chemicals in a Federal Register Notice, Draft List of Initial Pesticide Active Ingredients and Pesticide Inerts to be Considered for Screening under the Federal Food, Drug and Cosmetic Act (PDF) (18pp, 131K, About PDF).
- September 2005 – EPA Published a final approach for chemical selection. EPA reviewed comments received in response to the proposed approach and published a final Chemical Selection Approach for Initial Screening (PDF) (17pp, 125K, About PDF) in a Federal Register Notice.
- 1998-2002: EPA developed a priority setting approach for chemical selection. This approach incorporated recommendations made by a Federal advisory committee, the Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC), in a report issued in August 1998. To accomplish this, EPA established an internal intra-Agency Priority Setting Workgroup that met regularly to address priority setting in the EDSP. EPA initially published a Proposed Chemical Selection Approach for Initial Tier 1 Screening (PDF) (19pp, 119K, About PDF) in a Federal Register Notice for comment in December 2002.
Visit the links below to learn more about the initial list:
- Overview of the Initial List of Chemicals for Tier 1 Screening
- Overview of the Draft Initial List of Chemicals for Tier 1 Screening
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Chemical Selection Approach for the Initial List of Chemicals for Tier 1 Screening