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Policies and Procedures for the Endocrine Disruptor Screening Program

On this page you will find:

Work Plan to Improve Evaluation of Chemicals in the Endocrine Disruptor Screening Program

EPA released an overview summary of the Agency’s work plan (6pp, 791K, About PDF) to improve the scientific methods used to evaluate chemicals that may impact the endocrine system in people and animals. This work plan relies on scientific advancements in computational modeling, molecular biology, toxicology, and advanced robotics. By incorporating these scientific advancements into evaluating chemicals under the EDSP, EPA will prioritize and screen chemicals with greater speed, efficiency, and accuracy, while minimizing the use of laboratory animals.   

The work plan, referred to as EDSP21, follows recommendations made by the National Research Council (NRC) in a 2007 report on toxicity testing. Since EPA is required to complete registration review of registered pesticides by October 2022, new tools are needed to more quickly and efficiently screen and assess these pesticides. Development and validation of these new tools will be a multiyear process. As these new tools become ready for use, the EDSP will transition to rely on computational toxicology methods and high throughput screens to more quickly and cost-effectively assess potential chemical toxicity while minimizing the use of conventional whole animal studies. The workplan summary describes this transition.    

Policies and Procedures for Screening Safe Drinking Water Act Chemicals

November 17, 2010 - Draft Policies and Procedures for Screening Safe Drinking Water Act Chemicals. This document describes EPA’s draft policies and procedures for requiring Tier 1 screening of substances for which EPA may issue testing orders pursuant to section 1457 of the Safe Drinking Water Act (SDWA) and section 408(p) of the Federal Food, Drug, and Cosmetic Act (FFDCA). This document was drafted with the intent of explaining the policies and procedures relevant to EDSP SDWA chemicals. These draft policies and procedures are intended to supplement the existing EDSP policies and procedures (20 pp, 123KB, About PDF) that were published in the Federal Register on April 15, 2009 (74 FR 17560).

Additional supporting information is provided below:

How to Comment on the Draft Policies and Procedures for Screening SDWA Chemicals

Comments will be accepted on or before January 18, 2011. All comments should be identified by docket identification (ID) no. EPA-HQ-OPPT-2007-1080.

Submit relevant information, identified by docket identification (ID) number EPA-HQ-OPPT-2007-1080, by one of the following methods:

For further information contact Susan Sharkey (sharkey.susan@epa.gov or 202-564–8789) or Bill Wooge (wooge.william@epa.gov or 202-564-8476).

November 17, 2010 - EPA published a Draft Addendum for the Second List of Chemicals; Tier 1 Screening of Certain Chemicals Under the Endocrine Disruptor Screening Program (EDSP). The draft ICR describes the information collection activities associated with Tier 1 screening of the second list of chemicals under the EDSP and provides EPA's estimates for the related paperwork burden and costs.

Additional supporting information is provided below:

How to Comment on the Amendment to the Existing Information Collection Request (ICR)

Comments will be accepted on or before January 18, 2011. All comments should be identified by docket identification (ID) no. EPA-HQ-OPPT-2007-1081.

Submit relevant information, identified by docket identification (ID) number EPA-HQ-OPPT-2007-1081, by one of the following methods:

For further information contact Susan Sharkey (sharkey.susan@epa.gov or 202-564–8789) or Bill Wooge (wooge.william@epa.gov or 202-564-8476).

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Policies and Procedures for Screening Pesticides

April 15, 2009 – EPA published in the Federal Register the Revised Policies and Procedures for the Endocrine Disruptor Screening Program (PDF) (20 pp, 123K, About PDF) that EPA has adopted, including the statutory requirements associated with and format of the test orders, as well as EPA's procedures for fair and equitable sharing of test costs and data confidentiality. The revised policies and procedures include revisions made to the document after considering the public comments submitted to EPA during a public comment period on the December 2007 draft version of policies and procedures. Some of the changes and/or clarifications to the draft policies and procedures include:

 A Response to Comments on the DRAFT Endocrine Disruptor Screening Program (EDSP):Policies & Procedures for Initial Screening and Testing (27 pp, 109K, About PDF) document was prepared that provides a detailed review of the public comments and how EPA considered them in the revised policies and procedures.

December 13, 2007 -- EPA issued two Federal Register (FR) notices seeking public comment on the Endocrine Disruptor Screening Program:

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