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EDRI Federal Project Inventory:
Neuroendocrine Pathways Controlling Male and Female Reproduction Associated with the Gulf War Syndrome
- Sponsor Organization: NAVAL MEDICAL RESEARCH INSTITUTE DETACHMENT (TOXICOLOGY)
- Project Title: NEUROENDOCRINE PATHWAYS CONTROLLING MALE AND FEMALE REPRODUCTION
ASSOCIATEDWITH THE GULF WAR SYNDROME.
- Project Focus: HUMAN HEALTH EFFECTS
- Description: The hormonal regulation of the male and female gonad represents a
novel methodof toxicology that requires assessment of functional
endpoints that measure thepituitary-adrenal-gonadal feedback
mechanisms. To simply assess gonad changeshistologically or through
fertility endpoints provides limited data relating to mechanismof
action of reproductive toxicants. The staging of the reproductive
cycle in both sexesis critical to the understanding of how endocrine
disruptors mimic or interrupt hormonefunction. Mean gonadotrophin
levels, pulsality, endocrine system sensitivity and anunderstanding of
the normal function (control animals), is essential to the
interpretationof effects of xenobiotics on the reproductive process.
The monitoring and measuring ofchemical biomarker endpoints that
evaluate pituitary sensitivity, adrenal function andgonadal response
and normal fertilization and maintenance of the conceptus.
Theevaluation of neuroendocrine function by evaluating potential sites
of toxic vulnerabilityrequires study of endocrine support mechanisms
during gonad development,fertilization, implantation, pregnancy, birth
and post partum development of the infant.
- References: Culler, Michael D. (1996). The Female Reproductive System-How to
AssessPotential Toxicity. Continuing Education Course PM #11, Society
of Toxicology 35thAnnual Meeting, Anaheim, California, March.Abou-
Donia, M.B. et.al., (1996). Neurotoxicity resulting from coexposure
topyridostigmine bromide, DEET, and permethrine: Implications of Gulf
War chemicalexposures. Journal of Toxicology and Environmental Health,
48:35-56.
- Category: METHODS
- Subcategory: HAZARD IDENTIFICATION, MILITARY TOXICOLOGY, GULF WAR SYNDROME,
NEUROENDOCRINEDISRUPTION OR MIMICKING, RODENT BIOMARKERS
- Keywords for Experimental System/Species: IN VIVO, RAT: INVITRO, NEUROENDOCRINE BIOASSAYS, CHICKENS
- Keywords for Experimental Endpoints: NEUROLOGICAL, REPRODUCTIVE, MILITARY TOXICOLOGY, GULF WAR SYNDROME,
EXPOSUREIDENTIFICATION, TOXICOLOGY CHARACTERIZATION, RISK ASSESSMENT,
PHYSIOLOGICALLY BASED-PHARMACOKINETICS (PBPK) METHODS
- Chemical Agents: Pyridostigmine bromide, DEET, permethrine, pesticides, ozone
depletingsubstances, DBNP, solvents, methoxyfluorine, pentobarbital,
methoxychlor, suretychemicals
- Performing Institution: Naval Medical Research Institute Detachment (Toxicology); 2612 Fifth
Street, AreaB, Building 433; Wright-Patterson AFB, Ohio 45433-7903
- Contact: CAPT Kenneth R. Still MSC, USN; Comm: (513) 255-6058, DSN: 785-6058;
E-Mail:kstill@navy.al.wpafb.af.mil
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