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Research Product
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Mayer, Foster L., Gary F. Krause, Mark R. Ellersieck and Gunhee Lee. 1992. Statistical Approach to Predicting Chronic Toxicity of Chemicals to Fishes from Acute Toxicity Test Data. EPA/600/R-92/091//EPA/SW/DK-92/047. U.S. Environmental Protection Agency, Environmental Research Laboratory, Gulf Breeze, FL. 94 p. (Avail. from NTIS, Springfield, VA: PB92-169655; PB92-503119 with diskette)
A comprehensive approach to predicting chronic toxicity from acute toxicity data was developed in which simultaneous consideration is given to concentration, degree of response, and time course of effect. A consistent endpoint (lethality) and degree of response (0%) were used to compare acute and chronic tests. Predicted no-effect concentrations were highly accurate 92% of the time (within a factor of 2.0 of the limits of the maximum acceptable toxicant concentrations for lethality) and did not vary by more than a factor of 4.8 when the technique was applied to a data base of 18 chemicals and 7 fish species. Growth effects can be predicted from chronic lethality, but reproductive effects should not be. |
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