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Tan, Barrie, Melvin V. Kilgore, David L. Elam, Paul Melius and W.P. Schoor. 1981. Metabolites of Benzo(a)pyrene in Aroclor 1254 Treated Mullet. In: Aquatic Toxicology and Hazard Assessment, ASTM STP 737. D.R. Branson and K.L. Dickson, Editors. American Society for Testing and Materials, Philadelphia, PA. Pp. 239-246. (ERL,GB X267).

This paper presents a systematic approach to the separation and characterization of benzo(a)pyrene (BaP) metabolites using the efficient analytical technique of high pressure liquid chromatography (HPLC). Hepatic (S-9) preparations from Aroclor 1254 treated mullet (Mugil cephalus) were used to study the in vitro metabolism of (BaP). The lipid-soluble hydroxylated products were extracted in ethyl acetate prior to HPLC analysis. Three diols (9,10; 7,8; and 4,5) and two phenols (9 and 3) of (BaP) were isolated and identified from their unresolvable quinones. The results obtained in the mullet were compared to those obtained in the rat (Rattus norvegicus).

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