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MacDonell, M.T., B.A. Ortiz-Conde, G.A. Last and R.R. Colwell. 1986. Distribution of Mutations in Gram Negative Eubacterial 5S Ribosomal RNA Species and Significance for Sequence Analysis. J. Microbiol. Methods. 5(5-6):293-302. (ERL,GB X519).

Alignments of 72 5S rRNAs from Gram negative Eubacteria were used to derive a position-wise frequency distribution of mutations along the 5S rRNA molecule. These empirically derived, position-wise frequencies were used as coefficients for preparation of difference matrices and construction of evolutionary trees. Significance of the observed distribution of mutations in the 5S rRNAs, prepared for the Gram negative eubacteria, as well as its relationship to secondary structure are discussed.

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