Hazard and Dose-Response Assessment
EPA’s Office of Research and Development (ORD) develops hazard and dose-response assessments for environmental contaminants. For example, the Integrated Risk Information System (IRIS) is a human health assessment program that evaluates information on health effects that may result from exposure to environmental contaminants. Through the IRIS Program, EPA provides high quality science-based human health assessments to support the Agency's regulatory activities. The IRIS database is web accessible and contains information on more than 550 chemical substances. Additionally, ORD develops Provisional Peer Reviewed Toxicity Values (PPRTV) for the Superfund Program. PPRTVs are hazard and dose-response assessments for chemicals of concern at Superfund sites. These are developed in the absence of IRIS assessments. ORD also develops computational toxicology tools that can be used to inform our understanding of chemical hazard.