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JEFFRE C. JOHNSON
RESEARCH CHEMIST
Exposure and Dose Research Branch
Human Exposure and Atmospheric Sciences Division
EDUCATION/TRAINING
MS Chemistry, University of Illinois at Urbana-Champaign, 1987
BS, Chemistry, University of Wisconsin-Madison, 1982
Graduate level studies in computer science, Algorithmics, UNLV dept of Computer Science,
PROFESSIONAL EXPERIENCE
Research Chemist, US EPA, NERL, 1991 to present
Chemist, USDA, ARS, WHNRC, 1988-1991
Chemist, Tucson Water, 1987
SELECTED AWARDS AND HONORS
US EPA, Exceptional/Outstanding ORD Technical Assistance to the Regions or Program Offices, 2007
SELECTED PUBLICATIONS
Johnson, J.C., Dellarco, M., Harper, S.L., Chang, D. T., Dary, C. C., The Use of Time-Motion Video Analysis to Establish Dermal Transfer Coefficients for Residential Microenvironments, In Preparation.
Johnson, J. C., Van Emon, J. M., Clarke, A. N., Wamsley, B. N. Quantitative ELISA of Polychlorinated Biphenyls in an Oily Soil Matrix Using Supercritical Fluid Extraction, Analytica Chimica Acta, 428(2), 191-199, 2001.
Van Emon, J. M., Gerlach, C. L., Johnson, J. C., Immunoassay Test Kits in Environmental Monitoring in Current Issues in Regulatory Chemistry, pp. 135-150, AOAC International, Gaithersburg, MD, 2000.
Chuang, J. C., Miller, L. S., Davis, D. B., Peven, C. S., Johnson, J. C., Van Emon, J. M. Analysis of Soil and Dust Samples for Polychlorinated Biphenyls by Enzyme-linked Immunosorbent Assay (ELISA), Analytica Chimica Acta, 376(1): 67-75, 1998.
Johnson, J. C., Van Emon, J. M., Pullman, D. R., Keeper, K. R. Development and Evaluation of Antisera for Detection of the O,O-Diethyl Phosphorothionate and Phosphorothionothiolate Organophosphorous Pesticides by Immunoassay Journal of Agricultural and Food Chemistry, 46(8): 3116-3123, 1998. Johnson, J. C., Van Emon, J. M. Quantitative Enzyme-linked Immunosorbent Assay for Determination of Polychlorinated Biphenyls in Environmental Soil and Sediment Samples Analytical Chemistry, 68(1): 162-169, 1996
Johnson, J. C., Van Emon, J. M. Development and Evaluation of a Quantitative Enzyme Linked Immunosorbent Assay (ELISA) for Polychlorinated Biphenyls EPA/600/R-94/113, June 1994
Van Emon, J. M., Johnson, J. C., Rogers, K. R, Gerlach, R. W., White, R. J., O’ Leary, N. F. D., Hess, E. C., Hubert, E. W., Hamilton, D. W. Superfund Innovative Technology Evaluation (SITE) of Immunoassays for BTX Screening in Water and PCB Screening in Soil Proceedings of the 3rd International Symposium of Field Screening Methods for Hazardous Waste and Toxic Chemicals, Las Vegas, NV, February 1993
Van Emon, J. M, Gerlach, C. L., Johnson, J. C., eds., Environmental Immunochemical Methods: Perspectives and Applications ACS Symposium Series, American Chemical Society, Washington, DC 1996
SELECTED PRESENTATIONS
Zhang, X., Okino, M.S., Knaak, J.B., Tsang, A.M., Power, F.W., Xue, J., Harrison, L.S., Gerlach, R.W., Heravi, N.E., Johnson, J.C., Dary, C.C, A Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model for Estimation of Cumulative Risk from Exposure to Three N-Methyl Carbamates: Carbaryl, Aldicarb, and Carbofuran , 46th Annual Society of Toxicology Meeting, Charlotte, NC, March 25—29, 2007.
D. T. Chang, M.S.Okino, R. Tornero-Velez, J. B. Knaak, K. Enslein, F.W. Power, J. C. Johnson, C. S. Mazur, J. F. Kenneke, M. E. Dellarco, T. Collette and C. C. Dary, Suitability of Using QSAR to Generate Computationally Estimated Parameters in PBPK/PD Models, International Science Forum on Computational Toxicology, Research Triangle Park, NC, May 2007
D. T. Chang, T. L. Whitehead, M. S. Okino, J. F. Kenneke, C. S. Mazur, R. Tornero-Velez, J. Johnson and C. C. Dary, An In Silico Investigation of the Enantioselective Metabolism Rates of Triazole Fungicides, 14th Annual North American International Society for the Study of Xenobiotics Meeting, Rio Grande, Puerto Rico, October 2006
Johnson, J. C., Van Emon, J. M., Chuang, J. C. Quantitative ELISA of Polychlorinated Biphenyls in an Oily Soil Matrix Poster presented at Immunochemistry Summit VII & Third Workshop on Biosensors and Biological Techniques in Environmental Analysis, Las Vegas, NV, December 1-3, 1998.
Johnson, J. C., Van Emon, J. M., Chuang, J. C., Clarke, A. N., Wamsley, B. M., Reevaluation of Polychlorinated Biphenyl Contaminated Gencorp Lawrence Soil Using Quantitative Immunoassay presented at the 214th American Chemical Society National Meeting, Las Vegas, NV, September 7-11, 1997.
Johnson J. C., Van Emon, J. M., Immunoassay Test Kits in Environmental Monitoring presented at the 111th AOAC International Annual Meeting, San Diego, CA, September 7-11, 1997.
Johnson, J. C., Van Emon, J. M. An Immunochemical Approach Toward Class Detection of Organophosphate Pesticides, presented at the 212th American Chemical Society National Meeting, Orlando, FL, August 25-29, 1996.
Johnson, J. C. Immunoassay Analytical Issues and Case Studies presented at the U.S. EPA Immunoassay Technology Workshop, Chicago, IL, March 28-29, 1995.
Johnson, J. C., Van Emon, J. M.., Rogers, K. R, Gerlach, R. W., White, R. J., O’ Leary, N. F. D., Hess, E. C., Hubert, E. W., Hamilton, D. W. Superfund Innovative Technology Evaluation (SITE) of Immunoassays for BTX Screening in Water and PCB Screening in Soil presented at 3rd International Symposium on Field Screening Methods for Hazardous Waste and Toxic Chemicals, Las Vegas, NV, February 1993.
Dill, K., McGown, E. L., VanEmon, J. M., Johnson, J. C. Fluorescence-Based Immunoassays presented at Immunochemistry Summit VII & Third Workshop on Biosensors and Biological Techniques in Environmental Analysis, Las Vegas, NV, December 1-3, 1998. Van Emon, J. M, Johnson, J. C. Integration of Immunochemistry into the Analytical Laboratory presented at Pittcon 95, New Orleans, LA, March 4-10, 1995.
Van Emon, J. M., Johnson, J. C. SFE-ELISA Solutions to Pesticide Analysis presented at Pittcon 94, Chicago, IL, February 28, 1994.
Van Emon, J. M., Johnson, J. C., Rogers, K. R. Environmental Applications of Immunochemical Methods presented at the Pacific Conference on Chemistry and Spectroscopy, Foster City, CA, October 20-21, 1992.
NARRATIVE
My expertise is in matching the emergent high performance computing needs of current and future pharmacokinetic modeling studies within HEASD/EDRB with the development of the necessary higher throughput algorithms. In particular, linkage of stochastic exposure models with PBPK models, an emergent area, will tax current PBPK modeling systems beyond the limits of computational tractability. Thus, I am developing PBPK models for high performance computing (HPC) environments, with end targets being parallelized, high throughput PBPK models. I have extensive expertise in PBPK modeling within the framework of the exposure related dose estimating model (ERDEM) in particular with regard to n-methyl carbamate cumulative risk assessment for carbaryl, aldicarb, and carbofuran.