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Dr. Miles S. Okino
RESEARCH PHYSICAL SCIENTIST
Exposure and Dose Research Branch
Human Exposure and Atmospheric Sciences Division
EDUCATION/TRAINING
B.S. Chemistry and Chemical Engineering 1994, University of California, Berkeley
Ph.D. Chemical Engineering 1998, Northwestern University
PROFESSIONAL EXPERIENCE
Research Physical Scientist, NERL-HEASD-EDRB, Las Vegas, 2004 – present
Biologic Systems Engineer, Entelos, Inc., 2000 – 2003
Postdoctoral Researcher, NERL-HEASD-HERB, Las Vegas, 1998 – 2000
Adjunct Professor, Community College of Southern Nevada, 1999 – 2000
SELECTED AWARDS AND HONORS
U.S. EPA\ORD Bronze Medal: Trichloroethylene NAS Issue Papers, 2004
U.S. EPA\ORD\NERL Goal 1 Award: Carbamate Risk Assessment, 2006
U.S. EPA\ORD Technical Assistance Award: PBPK Modeling Team, 2007
SELECTED PUBLICATIONS (2005 to present, 9 of 19)
Okino MS, Power FW, Holbrook CM, Knaak JB, Harrison LS, Tornero-Velez R, Blancato JN, Quackenboss JJ, Lu C, Brown RN, Dary CC “Adaptation of a PBPK Model of Chlorpyrifos for Evaluation of Urine Biomarker Data” Journal of Exposure Science and Environmental Epidemiology, submitted.
Thompson CB, Okino MS, Chapa G, Power FW, Tsang AM, Dary CC “Urinary Biomarker Data Analysis for Children Along the U.S.- Mexico Border” Journal of Exposure Science and Environmental Epidemiology, submitted.
Mosquin PL, Collins Licata A, Liu B, Sumner SCJ, Okino MS “Reconstructing exposures from small samples using PBPK models and multiple biomarkers” Journal of Exposure Science and Environmental Epidemiology, submitted.
Zhang X, Tsang AM, Okino MS, Power FW, Knaak JB, Dary CC “A Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model for Carbofuran Using the Exposure Related Dose Estimating Model (ERDEM)” Toxicological Sciences, in press.
Knaak, J.B., Dary, CC, Okino MS, Power FW, Zhang, X., Thompson, CB, Tornero-Velez, R, Blancato, J.N. “Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment” Reviews of Environmental Contamination and Toxicology, in press.
Mazur CS, Kenneke JF, Tebes-Stevens C, Okino MS, Lipscomb JC. In vitro metabolism of the fungicide and environmental contaminant trans-bromuconazole and implications for risk assessment. J Toxicol Environ Health A. 2007 Jul;70(14):1241-50.
Chiu, W.A.; Okino, M.S.; Lipscomb, J.C.; Evans, M.V. “Issues in the Pharmacokinetics of Trichloroethylene and Its Metabolites” Environmental Health Perspectives, 2006;114(9):1450-6.
Caldwell, J.C.; Evans, M.V.; Marcus, A.H.; Scott, C.S.; Chiu, W.A.; Okino, M.S.; Preuss, P.W. “Comments on Article ‘Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene’ by Clewell and Andersen” Critical Reviews in Toxicology 2006; 36(3): 291-294.
Okino MS, Chiu WA, Evans MV, Power FW, Lipscomb JC, Tornero-Velez R, Dary CC, Blancato JN, Chen C, Birnbaum LS. “Suitability of Using In Vitro and Computationally Estimated Parameters in Simplified Pharmacokinetic Models.” Drug and Metabolism Reviews 2005; 37(suppl. 2):162.
SELECTED PRESENTATIONS (2005 to present, 8 of 26)
Okino, MS; Morgan MK; Gerlach R; Tsang, AM; Tornero-Velez, R; Power, FW; Chang, DT; Dary, CC “Comparison of forward and reverse dosimetry estimates using urinary biomarkers of exposure from the CTEPP study” Society of Risk Analysis Annual Meeting, December 9-12, 2007, San Antonio, TX.
Okino, MS; Morgan MK; Thompson, CB; Thomas K; Quackenboss, JJ; Chapa, G; Tornero-Velez, R; Tsang, A; Power, FW; Dary, CC “Analysis of urinary biomarker data using pharmacokinetic models to assess exposure” Society of Risk Analysis Annual Meeting, December 3-6, 2006, Baltimore, MD (invited).
Okino, MS; Thompson, CB; Power, FW; Tornero-Velez, R; Tsang, A; Blancato, JN; Dary, CC “Urinary biomarker interpretation using pharmacokinetic models” International Council of Chemistry Association Workshop (Making Sense of of Human Biomonitoring Data) July 26-27, 2006, Minneapolis, MN.
Okino M.S., Evans, M.V., Power F.W., Chiu, W.A., Lipscomb, J., Blancato, J.N., Chen, C. “Evaluation of Multiple Pharmacokinetic Modeling Structures for Trichloroethylene.” Society of Toxicology Annual Meeting 2006, March 5-9, 2006, San Diego, CA.
Okino MS, Chapa G, Thomas K, Robertson G, Thompson CB, Tsang A, Power FW, Knaak JB, Dary CC “Use of Pharmacokinetic Models to Assess Occupational and Residential Pesticide Exposure” Internation Society for Exposure Analysis Annual Meeting 2005, October 30-November 3, 2005, Tucson, AZ.
Okino MS, Evans MV, Isukapalli SS, Wang SW, Georgopoulos PG, Karstadt M, Tornero-Velez R, DeVito M, Birnbaum L, Blancato JN, Geller AM “Evaluating Risk in Older Adults Using Physiologically Based Pharmacokinetic Models” EPA Science Forum 2005, May 16-18, 2005, Washington DC.
Okino M.S., Power F.W., Knaak J.B., Tornero-Velez R., Lunchick C., Lowit A., Blancato J.N. and Dary C.C. “Use of a Physiologically-Based Pharmacokinetic Model to Estimate Absorbed Carbaryl Dose in Children after Turf Application.” Society of Toxicology Annual Meeting 2005, March 6-10, 2005, New Orleans, LA (poster).
Okino, M.S.; Power FW; Dary, C.C.; Tornero-Velez, R.; Blancato, JN “Assessment Of Carbaryl Exposure Following Turf Application Using A Physiologically Based Pharmacokinetic Model.” FIFRA Scientific Advisory Panel (SAP) Open Meeting, February 15-18, 2005, Docket Number: OPP-2004-0405, Washington DC.
NARRATIVE
Dr. Miles Okino’s research interests are the development, simplification, and analysis of complex mathematical models towards applications of human environmental exposure and health. Current projects are focused on evaluating the links among exposure, dose, and risk with physiologically-based pharmacokinetic and pharmacodynamic (PBPK/PD) models. Goals of the research are to reduce uncertainty in risk assessment and enhance the design and interpretation of observational studies. Previous research includes systems biology modeling of the adaptive and innate immune systems in a model of asthma for pharmaceutical applications, and simplification of chemical reaction systems for process control.