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Dr. Rogelio Tornero-Velez
RESEARCH PHYSICAL SCIENTIST
Exposure and Dose Research Branch
Human Exposure and Atmospheric Sciences Division
EDUCATION/TRAINING
PhD, Environmental Sciences and Engineering, 2001, University of North Carolina
MSPH, Environmental Sciences and Engineering, 1994, University of North Carolina
BS, Chemistry, 1989, University of North Carolina
PROFESSIONAL EXPERIENCE
Research Physical Scientist, US EPA, NERL, 2005 to present
Postdoctoral Fellow, US EPA, NERL, 2002 to 2005
Postdoctoral Fellow, UNC/EPA Cooperative Agreement, 2001 to 2002
SELECTED AWARDS AND HONORS
US EPA, Exceptional/Outstanding ORD Technical Assistance to the Regions or Program Offices, 2007
US EPA, ORD Teamwork Award, 2006
US EPA, NERL Special Achievment Award, 2006
SELECTED PUBLICATIONS (8 out of 12 from 2000 to present)
M.-R. Goldsmith, D.T. Chang, R. Tornero-Velez, S. Little, M. Pasquinelli, J. Rabinowitz, and C.C. Dary. A Consensus Docking Study on the Stereoselectivity of Pyrethroid-like Compounds in Carboxylesterase (in preparation).
Mirfazaelian A, Kim KB, Anand SS, Kim HJ, Tornero-Velez R, Bruckner JV, Fisher JW. (2006). Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague-Dawley rat. Toxicol Sci. 93(2):432-42.
Granville CA, Ross MK, Tornero-Velez R, Hanley NM, Grindstaff RD, Gold A, Richard AM, Funasaka K, Tennant AH, Kligerman AD, Evans MV, DeMarini DM. (2005). Genotoxicity and Metabolism of the Source-Water Contaminant 1,1-Dichloropropene: Activation by GSTT1-1 and Structure-Activity Considerations Mutat Res 572 (1-2):98-112.
Lipscomb J, Barton H, Tornero-Velez R, Evans MV, Alcasey S, Snawder JE, Laskey J. (2004). The Metabolic Rate Constants and Specific Activity of Human and Rat Hepatic Cytochrome P450 2E1 Toward Chloroform. Journal of Toxicology and Environmental Health 67:1-17 .
Luderer U, Tornero-Velez R, Shay T, Rappaport S, Heyer N, Echeverria D. (2004) . Temporal association between serum prolactin concentration and exposure to styrene. Occup Environ Med. 61:325-33,
Tornero-Velez R, Ross MK, Granville C, Laskey J, Jones JP, DeMarini DM, Evans MV Metabolism and Mutagenicity of Source Water Contaminants 1,3-Dichloropropane and 2,2-Dichloropropane (2004). Drug Metabolism and Disposition 32:123-131.
Tornero-Velez R, Rappaport, SM. (2001). Physiologically Modeling of the Relative Contributions of Styrene-7,8-oxide Derived from Direct Inhalation and from Styrene Metabolism upon the Systemic Dose in Humans. Toxicological Sciences, 64: 151-161.
Egeghy PP, Tornero-Velez R, Rappaport SM (2000). Environmental and biological monitoring of benzene during self-service automobile refueling. Environmental Health Perspectives 108(12):1195-1202.
SELECTED PRESENTATIONS (12 out of 15 from 1996 to present)
R. Tornero-Velez. (2007) Physiologically-Based Pharmacokinetic Modeling Approaches: Pyrethroid Pesticides. Presented to the FIFRA Scientific Advisory Panel (SAP) Open Meeting, Arlington, VA.
R. Tornero-Velez, E.J. Scollon, J. Starr, M.F. Hughes, M.J. DeVito, C.C. Dary. (2006) Pharmacokinetic/Pharmacodynamic Modeling of Permethrin in the Rat. Presented at the 46th annual meeting of the Society of Toxicology, Charlotte, NC
D.T. Chang, M.-R. Goldsmith, R. Tornero-Velez, R. Rabinowitz and C.C. Dary. 2007. Utilizing In Silico Techniques to Elucidate the Stereoselective Behaviour of Pyrethroids within Carboxylesterase. 234th ACS National Meeting, Modern Chiral Agrochemicals: the Importance of Enantioselectivity in Fate and Effects Symposium, Boston, MA (invited).
D.T. Chang, T.L. Whitehead, M.S. Okino, J.F. Kenneke, C.S. Mazur, R. Tornero-Velez, J. Johnson and C.C. Dary. 2006. An In Silico Investigation of the Enantioselective Metabolism Rates of Triazole Fungicides, 14th Annual North American International Society for the Study of Xenobiotics Meeting, Rio Grande, Puerto Rico.
D.T. Chang, P.P. Egeghy, J.B. Knaak, R. Tornero-Velez, M.S. Okino, F.W. Power, M.E. Dellarco, C.S. Mazur, J.F. Kenneke and C.C. Dary. 2006. Influence of Matrix Formulation on Dermal Percutaneous Absorption of Triazole Fungicides Using QSAR and PBPK/PD Models, International Society of Enviromental Epidemiology/International Society of Exposure Analysis International Conference on Environmental Epidemiology and Exposure, Paris, France.
J.B. Knaak, D.T. Chang, C.C. Dary, R. Tornero-Velez, M.S. Okino and F.W. Power. 2005. Estimation of Adipose Tissue:Blood Partition Coefficients of Carbamates and Organophosphorous (OP) Pesticides Using Relative Lipid Content and LogP as the Mechanistic Determinants, 230th ACS National Meeting, Washington, DC.
R. Tornero-Velez, C.C. Dary, M. Dellarco, J.N. Blancato. (2004). A PBPK model of pyrethroid pesticides for application in risk assessment. Presented at the X2004, Utrecht, The Netherlands.
R. Tornero-Velez, H. Nichols, M.V. Evans, M.J. DeVito, C.C. Dary. (2004). Towards a Generic PBPK Model of Pyrethroid Pesticides : Modeling Deltamethrin and Permethrin in the Rat. Presented at the 43rd annual meeting of the Society of Toxicology, Baltimore, MD.
R. Tornero-Velez, C.C. Dary, J.B. Knaak, F. Power, M.E. Dellarco, E. Furtaw, J.N. Blancato. (2003). A Comparative Investigation of the Influence of Dermal Appendages (hairfollicles) on the Percutaneous Absorption of Organophosphorus (OP) Insecticides using QSAR and PBPK/PD Models for Human Risk Assessment presented at 13th Annual meeting of the International Society of Exposure Analysis, Stresa, Lago Maggiore, Italy.
R Tornero‑Velez, J Laskey, and M.V. Evans (2003). In Vitro Determination of kinetic constants for 1,3‑dichloropropane, 2,2‑dichloropropane, and 1,1‑dichlorpropene in rat liver microsomes and cytosol. Presented at the 42nd annual meeting of the Society of Toxicology, Salt Lake City, Utah.
R Tornero-Velez, J Laskey, H Barton, J Lipscomb, and MV Evans. (2002). In Vitro Determination of Metabolic Constants for Chloroform in Human Microsomes presented at the 41st annual meeting of the Society of Toxicology, Nashville, TN .
R Tornero-Velez and SM Rappaport (1996). Compliance versus Risk in Assessing Occupational Exposures presented at the annual meeting and exposition of the Society for Risk Analysis and International Society of Exposure Analysis. New Orleans, LA.
NARRATIVE
My expertise is in exposure assessment and pharmacokinetic modeling. I have employed physiologically-based pharmacokinetic (PBPK) models to provide mechanistic insight into exposure-biomarker relationships. In my thesis work I used PBPK modeling to compare the relative importance of direct exposure to styrene-7,8-oxide (SO) versus SO formed via metabolism of inhaled styrene. These evaluations were aimed at understanding styrene exposures in reinforced plastics industry. PBPK modeling allowed explicit consideration of the so-called ‘privileged access’ mechanism of in-situ formed SO (from styrene). This mechanism helped explain the greater bioavailability of airborne SO (ppb) versus SO via styrene (ppm). I am currently developing PBPK models to describe pyrethroid disposition in humans following exposure though diet, residential use, or other pathways. Environmental exposures tend to pose a greater challenge than occupational exposures in that they are much less predictable. We are also developing models of exposure and coupling these to pharmacokinetic models. Ultimately these models will allow the Agency to replace its default approaches and consider the probabilistic nature of exposure, and take into account ADME in risk assessment.